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Research Database PMU-SQQUID


chosen keywordHistone

HDAC inhibitors in liver cancer: which route to take?
Kiesslich, T; Neureiter, D;
Expert Rev Gastroenterol Hepatol. 2019; 13(6):515-517
Originalarbeiten (Zeitschrift)
Targeting class I histone deacetylases by the novel small molecule inhibitor 4SC-202 blocks oncogenic hedgehog-GLI signaling and overcomes smoothened inhibitor resistance.
Gruber, W; Peer, E; Elmer, DP; Sternberg, C; Tesanovic, S; Del Burgo, P; Coni, S; Canettieri, G; Neureiter, D; Bartz, R; Kohlhof, H; Vitt, D; Aberger, F;
Int J Cancer. 2018; 142(5):968-975
Originalarbeiten (Zeitschrift)
HDAC-Linked "Proliferative" miRNA Expression Pattern in Pancreatic Neuroendocrine Tumors.
Klieser, E; Urbas, R; Swierczynski, S; Stättner, S; Primavesi, F; Jäger, T; Mayr, C; Kiesslich, T; Fazio, PD; Helm, K; Neureiter, D;
Int J Mol Sci. 2018; 19(9):
Originalarbeiten (Zeitschrift)
The histone methyltransferase G9a: a new therapeutic target in biliary tract cancer.
Mayr, C; Helm, K; Jakab, M; Ritter, M; Shrestha, R; Makaju, R; Wagner, A; Pichler, M; Beyreis, M; Staettner, S; Jaeger, T; Klieser, E; Kiesslich, T; Neureiter, D;
Hum Pathol. 2018; 72:117-126
Originalarbeiten (Zeitschrift)
Pharmacological Inhibition of Class IIA HDACs by LMK-235 in Pancreatic Neuroendocrine Tumor Cells.
Wanek, J; Gaisberger, M; Beyreis, M; Mayr, C; Helm, K; Primavesi, F; Jäger, T; Di Fazio, P; Jakab, M; Wagner, A; Neureiter, D; Kiesslich, T;
Int J Mol Sci. 2018; 19(10):
Originalarbeiten (Zeitschrift)
Panobinostat mediated cell death: a novel therapeutic approach for osteosarcoma.
Wirries, A; Jabari, S; Jansen, EP; Roth, S; Figueroa-Juárez, E; Wissniowski, TT; Neureiter, D; Klieser, E; Lechler, P; Ruchholtz, S; Bartsch, DK; Boese, CK; Di Fazio, P;
Oncotarget. 2018; 9(68):32997-33010
Originalarbeiten (Zeitschrift)
Comprehensive immunohistochemical analysis of histone deacetylases in pancreatic neuroendocrine tumors: HDAC5 as a predictor of poor clinical outcome.
Klieser, E; Urbas, R; Stättner, S; Primavesi, F; Jäger, T; Dinnewitzer, A; Mayr, C; Kiesslich, T; Holzmann, K; Di Fazio, P; Neureiter, D; Swierczynski, S;
Hum Pathol. 2017; 65: 41-52.
Originalarbeiten (Zeitschrift)
Consensus paper of the WFSBP Task Force on Biological Markers: Criteria for biomarkers and endophenotypes of schizophrenia, part III: Molecular mechanisms.
Schmitt, A; Martins-de-Souza, D; Akbarian, S; Cassoli, JS; Ehrenreich, H; Fischer, A; Fonteh, A; Gattaz, WF; Gawlik, M; Gerlach, M; Grünblatt, E; Halene, T; Hasan, A; Hashimoto, K; Kim, YK; Kirchner, SK; Kornhuber, J; Kraus, TFJ; Malchow, B; Nascimento, JM; Rossner, M; Schwarz, M; Steiner, J; Talib, L; Thibaut, F; Riederer, P; Falkai, P;
World J Biol Psychiatry. 2017; 18(5): 330-356.
Originalarbeiten (Zeitschrift)
[Operative technique for percutaneous nephrolithotomy].
Hacker, A; Bachmann, A; Herrmann, T; Homberg, R; Klein, J; Leyh, H; Miernik, A; Netsch, C; Olbert, P; Rassweiler, J; Schoenthaler, M; Sievert, KD; Westphal, J; Gross, AJ
UROLOGE. 2016; 55(10): 1375-1386.
Originalarbeiten (Zeitschrift)
Back to the start: Evaluation of prognostic markers in gastrointestinal stromal tumors.
Klieser, E; Pichelstorfer, M; Weyland, D; Kemmerling, R; Swierczynski, S; Dinnewitzer, A; Jäger, T; Kiesslich, T; Neureiter, D; Illig, R;
Mol Clin Oncol. 2016; 4(5): 763-773.
Originalarbeiten (Zeitschrift)
TIS7 induces transcriptional cascade of methylosome components required for muscle differentiation.
Lammirato, A; Patsch, K; Feiereisen, F; Maly, K; Nofziger, C; Paulmichl, M; Hackl, H; Trajanoski, Z; Valovka, T; Huber, LA; Vietor, I
BMC BIOL. 2016; 14(1): 95
Originalarbeiten (Zeitschrift)
In vivo monitoring of the anti-angiogenic therapeutic effect of the pan-deacetylase inhibitor panobinostat by small animal PET in a mouse model of gastrointestinal cancers.
Maschauer, S; Gahr, S; Gandesiri, M; Tripal, P; Schneider-Stock, R; Kuwert, T; Ocker, M; Prante, O;
Nucl Med Biol. 2016; 43(1): 27-34.
Originalarbeiten (Zeitschrift)
Association between miRNAs and HDACs in Pancreatic Neuroendocrine Tumors
Swierczynski, S; Klieser, E; Urbas, R; Stattner, S; Primavesi, F; Jager, T; Kiesslich, T; Kemmerling, R; Di Fazio, P; Neureiter, D
Abstracts (Zeitschrift)
The pan-deacetylase inhibitor panobinostat affects angiogenesis in hepatocellular carcinoma models via modulation of CTGF expression.
Gahr, S; Mayr, C; Kiesslich, T; Illig, R; Neureiter, D; Alinger, B; Ganslmayer, M; Wissniowski, T; Fazio, PD; Montalbano, R; Ficker, JH; Ocker, M; Quint, K;
Int J Oncol. 2015; 47(3):963-970
Originalarbeiten (Zeitschrift)
The pan-deacetylase inhibitor panobinostat suppresses the expression of oncogenic miRNAs in hepatocellular carcinoma cell lines.
Henrici, A; Montalbano, R; Neureiter, D; Krause, M; Stiewe, T; Slater, EP; Quint, K; Ocker, M; Di Fazio, P;
Mol Carcinog. 2015; 54(8): 585-597.
Originalarbeiten (Zeitschrift)
Endoplasmic Reticulum Stress in Pancreatic Neuroendocrine Tumors is Linked to Clinicopathological Parameters and Possible Epigenetic Regulations.
Klieser, E; Illig, R; Státtner, S; Primavesi, F; Jáger, T; Swierczynski, S; Kiesslich, T; Kemmerling, R; Bollmann, C; DI Fazio, P; Neureiter, D;
Anticancer Res. 2015; 35(11):6127-6136
Originalarbeiten (Zeitschrift)
Role of histone deacetylases in pancreas: Implications for pathogenesis and therapy.
Klieser, E; Swierczynski, S; Mayr, C; Schmidt, J; Neureiter, D; Kiesslich, T; Illig, R;
World J Gastrointest Oncol. 2015; 7(12): 473-483.
The role of polycomb repressive complexes in biliary tract cancer.
Mayr, C; Neureiter, D; Wagner, A; Pichler, M; Kiesslich, T;
Expert Opin Ther Targets. 2015; 19(3):363-375
Originalarbeiten (Zeitschrift)
Increased Acetylation of Histone H4 at Lysine 12 (H4K12) in Monocytes of Transgenic Alzheimers Mice and in Human Patients.
Plagg, B; Ehrlich, D; Kniewallner, KM; Marksteiner, J; Humpel, C;
Curr Alzheimer Res. 2015; 12(8): 752-760.
Originalarbeiten (Zeitschrift)
Digging deep into "dirty" drugs - modulation of the methylation machinery.
Pleyer, L; Greil, R;
Drug Metab Rev. 2015; 47(2):252-279
Originalarbeiten (Zeitschrift)
Histone deacetylation meets miRNA: epigenetics and post-transcriptional regulation in cancer and chronic diseases.
Swierczynski, S; Klieser, E; Illig, R; Alinger-Scharinger, B; Kiesslich, T; Neureiter, D;
Expert Opin Biol Ther. 2015; 15(5):651-664
Originalarbeiten (Zeitschrift)
Romidepsin for the treatment of relapsed/refractory peripheral T-cell lymphoma: pivotal study update demonstrates durable responses.
Coiffier, B; Pro, B; Prince, HM; Foss, F; Sokol, L; Greenwood, M; Caballero, D; Morschhauser, F; Wilhelm, M; Pinter-Brown, L; Iyer, SP; Shustov, A; Nielsen, T; Nichols, J; Wolfson, J; Balser, B; Horwitz, S
J Hematol Oncol. 2014; 7:11
Originalarbeiten (Zeitschrift)
Robust linear regression model of Ki-67 for mitotic rate in gastrointestinal stromal tumors.
Kemmerling, R; Weyland, D; Kiesslich, T; Illig, R; Klieser, E; Jäger, T; Dietze, O; Neureiter, D;
Oncol Lett. 2014; 7(3): 745-749.
Originalarbeiten (Zeitschrift)
From the nucleus to the plasma membrane: translocation of the nuclear proteins histone H3 and lamin B1 in apoptotic microglia.
Klein, B; Lütz-Meindl, U; Kerschbaum, HH;
Apoptosis. 2014; 19(5): 759-775.
Originalarbeiten (Zeitschrift)
Hyperactive Cdc2 kinase interferes with the response to broken replication forks by trapping S.pombe Crb2 in its mitotic T215 phosphorylated state.
Mahyous Saeyd, SA; Ewert-Krzemieniewska, K; Liu, B; Caspari, T;
Nucleic Acids Res. 2014; 42(12):773-747
Originalarbeiten (Zeitschrift)
Epigenetics and pancreatic cancer: Pathophysiology and novel treatment aspects.
Neureiter, D; Jäger, T; Ocker, M; Kiesslich, T;
World J Gastroenterol. 2014; 20(24): 7830-7848.
New Aspects on the Structure of Neutrophil Extracellular Traps from Chronic Obstructive Pulmonary Disease and In Vitro Generation
Obermayer, A; Stoiber, W; Krautgartner, WD; Klappacher, M; Kofler, B; Steinbacher, P; Vitkov, L; Grabcanovic-Musija, F; Studnicka, M
PLOS ONE. 2014; 9(5): e97784
Originalarbeiten (Zeitschrift)
Fontan-like circulation as a criterion for heart transplantation in arrhythmogenic right ventricular dysplasia.
Schernthaner, C; Poelzl, G; Strohmer, B; Steinacher, R; Granitz, M; Altenberger, J;
Wien Klin Wochenschr. 2014; 126(21-22):705-709
Originalarbeiten (Zeitschrift)
Epigenetic control of epithelial-mesenchymal-transition in human cancer.
Kiesslich, T; Pichler, M; Neureiter, D;
Mol Clin Oncol. 2013; 1(1): 3-11.
Endoplasmic reticulum stress plays a pivotal role in cell death mediated by the pan-deacetylase inhibitor panobinostat in human hepatocellular cancer cells.
Montalbano, R; Waldegger, P; Quint, K; Jabari, S; Neureiter, D; Illig, R; Ocker, M; Di Fazio, P
Transl Oncol. 2013; 6(2):143-157
Originalarbeiten (Zeitschrift)
Weaver syndrome and EZH2 mutations: Clarifying the clinical phenotype.
Tatton-Brown, K; Murray, A; Hanks, S; Douglas, J; Armstrong, R; Banka, S; Bird, LM; Clericuzio, CL; Cormier-Daire, V; Cushing, T; Flinter, F; Jacquemont, ML; Joss, S; Kinning, E; Lynch, SA; Magee, A; McConnell, V; Medeira, A; Ozono, K; Patton, M; Rankin, J; Shears, D; Simon, M; Splitt, M; Strenger, V; Stuurman, K; Taylor, C; Titheradge, H; Van Maldergem, L; Temple, IK; Cole, T; Seal, S; Rahman, N;
Am J Med Genet A. 2013; 161A(12): 2972-2980.
Originalarbeiten (Zeitschrift)
Combination of the deacetylase inhibitor panobinostat and the multi-kinase inhibitor sorafenib for the treatment of metastatic hepatocellular carcinoma - review of the underlying molecular mechanisms and first case report.
Gahr, S; Wissniowski, T; Zopf, S; Strobel, D; Pustowka, A; Ocker, M;
J Cancer. 2012; 3: 158-165.
Originalarbeiten (Zeitschrift)
Novel treatment avenues for peripheral T-cell lymphomas.
Hopfinger, G; Griessl, R; Sifft, E; Taylor, N; Kenner, L; Greil, R; Merkel, O;
Expert Opin Drug Discov. 2012; 7(12):1149-1163
Originalarbeiten (Zeitschrift)
The Rad4(TopBP1) ATR-activation domain functions in G1/S phase in a chromatin-dependent manner.
Lin, SJ; Wardlaw, CP; Morishita, T; Miyabe, I; Chahwan, C; Caspari, T; Schmidt, U; Carr, AM; Garcia, V;
PLoS Genet. 2012; 8(6):e1002801
Originalarbeiten (Zeitschrift)
Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC
Quint, K; Agaimy, A; Di Fazio, P; Montalbano, R; Steindorf, C; Jung, R; Hellerbrand, C; Hartmann, A; Sitter, H; Neureiter, D; Ocker, M
VIRCHOWS ARCH. 2011; 459(2): 129-139.
Originalarbeiten (Zeitschrift)
Two isoforms of the protein kinase pUL97 of human cytomegalovirus are differentially regulated in their nuclear translocation.
Webel, R; Milbradt, J; Auerochs, S; Schregel, V; Held, C; Nöbauer, K; Razzazi-Fazeli, E; Jardin, C; Wittenberg, T; Sticht, H; Marschall, M;
J Gen Virol. 2011; 92(Pt 3):638-649
Originalarbeiten (Zeitschrift)
Conditional deletion of histone deacetylase 1 in T cells leads to enhanced airway inflammation and increased Th2 cytokine production.
Grausenburger, R; Bilic, I; Boucheron, N; Zupkovitz, G; El-Housseiny, L; Tschismarov, R; Zhang, Y; Rembold, M; Gaisberger, M; Hartl, A; Epstein, MM; Matthias, P; Seiser, C; Ellmeier, W;
J Immunol. 2010; 185(6):3489-3497
Originalarbeiten (Zeitschrift)
A RAS recruitment screen identifies ZKSCAN4 as a glucocorticoid receptor-interacting protein.
Ecker, K; Lorenz, A; Wolf, F; Ploner, C; Böck, G; Duncan, T; Geley, S; Helmberg, A;
J Mol Endocrinol. 2009; 42(2):105-117
Originalarbeiten (Zeitschrift)
Increased soluble serum markers caspase-cleaved cytokeratin-18, histones, and ST2 indicate apoptotic turnover and chronic immune response in COPD.
Hacker, S; Lambers, C; Pollreisz, A; Hoetzenecker, K; Lichtenauer, M; Mangold, A; Niederpold, T; Hacker, A; Lang, G; Dworschak, M; Vukovich, T; Gerner, C; Klepetko, W; Ankersmit, HJ;
J Clin Lab Anal. 2009; 23(6): 372-379.
Originalarbeiten (Zeitschrift)
The histone-deacetylase inhibitor MS-275 and the CDK-inhibitor CYC-202 promote anti-tumor effects in hepatoma cell lines.
Gahr, S; Peter, G; Wissniowski, TT; Hahn, EG; Herold, C; Ocker, M;
Oncol Rep. 2008; 20(5): 1249-1256.
Originalarbeiten (Zeitschrift)
Differential response of p53 and p21 on HDAC inhibitor-mediated apoptosis in HCT116 colon cancer cells in vitro and in vivo.
Zopf, S; Neureiter, D; Bouralexis, S; Abt, T; Glaser, KB; Okamoto, K; Ganslmayer, M; Hahn, EG; Herold, C; Ocker, M;
INT J ONCOL. 2007; 31(6): 1391-1402.
Originalarbeiten (Zeitschrift)
Histone deacetylase inhibitors potently repress CXCR4 chemokine receptor expression and function in acute lymphoblastic leukaemia.
Crazzolara, R; Jöhrer, K; Johnstone, RW; Greil, R; Kofler, R; Meister, B; Bernhard, D;
Br J Haematol. 2002; 119(4): 965-969.
Originalarbeiten (Zeitschrift)
Inhibition of histone deacetylase activity enhances Fas receptor-mediated apoptosis in leukemic lymphoblasts.
Bernhard, D; Skvortsov, S; Tinhofer, I; Hübl, H; Greil, R; Csordas, A; Kofler, R;
Cell Death Differ. 2001; 8(10): 1014-1021.
Originalarbeiten (Zeitschrift)