Immune-mediated platelet depletion augments Alzheimers disease neuropathological hallmarks in APP-PS1 mice.
de Sousa, DMB; Benedetti, A; Altendorfer, B; Mrowetz, H; Unger, MS; Schallmoser, K; Aigner, L; Kniewallner, KM;
Aging (Albany NY). 2023; 15(3):630-649
Originalarbeiten (Zeitschrift)

The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery.
Gonzalez Melo, M; Remacle, N; Cudré-Cung, HP; Roux, C; Poms, M; Cudalbu, C; Barroso, M; Gersting, SW; Feichtinger, RG; Mayr, JA; Costanzo, M; Caterino, M; Ruoppolo, M; Rüfenacht, V; Häberle, J; Braissant, O; Ballhausen, D;
Mol Genet Metab. 2021; 133(2):157-181
Originalarbeiten (Zeitschrift)

The Leukotriene Receptor Antagonist Montelukast Attenuates Neuroinflammation and Affects Cognition in Transgenic 5xFAD Mice
Michael, J; Zirknitzer, J; Unger, MS; Poupardin, R; Riess, T; Paiement, N; Zerbe, H; Hutter-Paier, B; Reitsamer, H; Aigner, L
INT J MOL SCI. 2021; 22(5): 2782
Originalarbeiten (Zeitschrift)

Inhibition of the cysteinyl leukotriene pathways increases survival of RGCs and reduces microglial activation in ocular hypertension.
Trost, A; Motloch, K; Koller, A; Bruckner, D; Runge, C; Schroedl, F; Bogner, B; Kaser-Eichberger, A; Strohmaier, C; Ladek, AM; Preishuber-Pfluegl, J; Brunner, SM; Aigner, L; Reitsamer, HA;
Exp Eye Res. 2021; 213: 108806
Originalarbeiten (Zeitschrift)

Therapeutic Potential of Selenium in Glioblastoma.
Yakubov, E; Eibl, T; Hammer, A; Holtmannspötter, M; Savaskan, N; Steiner, HH;
Front Neurosci. 2021; 15:666679
Übersichtsarbeiten

Effect of Glycine on BV-2 Microglial Cells Treated with Interferon-γ and Lipopolysaccharide.
Egger, F; Jakab, M; Fuchs, J; Oberascher, K; Brachtl, G; Ritter, M; Kerschbaum, HH; Gaisberger, M;
Int J Mol Sci. 2020; 21(3):
Originalarbeiten (Zeitschrift)

Lipid-droplet-accumulating microglia represent a dysfunctional and proinflammatory state in the aging brain.
Marschallinger, J; Iram, T; Zardeneta, M; Lee, SE; Lehallier, B; Haney, MS; Pluvinage, JV; Mathur, V; Hahn, O; Morgens, DW; Kim, J; Tevini, J; Felder, TK; Wolinski, H; Bertozzi, CR; Bassik, MC; Aigner, L; Wyss-Coray, T;
Nat Neurosci. 2020; 23(2):194-208
Originalarbeiten (Zeitschrift)

Aging and Neurodegenerative Disease: Is the Adaptive Immune System a Friend or Foe?
Mayne, K; White, JA; McMurran, CE; Rivera, FJ; de la Fuente, AG
FRONT AGING NEUROSCI. 2020; 12: 572090
Übersichtsarbeiten

Microglia depletion diminishes key elements of the leukotriene pathway in the brain of Alzheimer"s Disease mice.
Michael, J; Unger, MS; Poupardin, R; Schernthaner, P; Mrowetz, H; Attems, J; Aigner, L
ACTA NEUROPATHOL COM. 2020; 8(1): 129
Originalarbeiten (Zeitschrift)

The role of the spinal cyclooxygenase (COX) for incisional pain in rats at different developmental stages.
Segelcke, D; Reichl, S; Neuffer, S; Zapp, S; Rüther, T; Evers, D; Zahn, PK; Pogatzki-Zahn, EM;
Eur J Pain. 2020; 24(2): 312-324.
Originalarbeiten (Zeitschrift)

CD8+ T-cells infiltrate Alzheimer’s disease brains and regulate neuronal- and synapse-related gene expression in APP-PS1 transgenic mice
Unger, MS; Li, E; Scharnagl, L; Poupardin, R; Altendorfer, B; Mrowetz, H; Hutter-Paier, B; Weiger, TM; Heneka, MT; Attems, J; Aigner, L;
Brain Behav Immun. 2020; 89: 67-86.
Originalarbeiten (Zeitschrift)

Extracellular vesicles from human multipotent stromal cells protect against hearing loss after noise trauma in vivo.
Warnecke, A; Harre, J; Staecker, H; Prenzler, N; Strunk, D; Couillard-Despres, S; Romanelli, P; Hollerweger, J; Lassacher, T; Auer, D; Pachler, K; Wietzorrek, G; Köhl, U; Lenarz, T; Schallmoser, K; Laner-Plamberger, S; Falk, CS; Rohde, E; Gimona, M;
Clin Transl Med. 2020; 10(8): e262
Originalarbeiten (Zeitschrift)

Acid- and Volume-Sensitive Chloride Currents in Microglial Cells.
Kittl, M; Helm, K; Beyreis, M; Mayr, C; Gaisberger, M; Winklmayr, M; Ritter, M; Jakab, M;
Int J Mol Sci. 2019; 20(14):
Originalarbeiten (Zeitschrift)

A Swelling-Activated Chloride Current in Microglial Cells is Suppressed by Epac and Facilitated by PKA - Impact on Phagocytosis.
Kittl, M; Jakab, M; Steininger, TS; Ritter, M; Kerschbaum, HH;
Cell Physiol Biochem. 2019; 52(5): 951-969.
Originalarbeiten (Zeitschrift)

Bone matrix hypermineralization associated with low bone turnover in a case of Nasu-Hakola disease.
Shboul, M; Roschger, P; Ganger, R; Paschalis, L; Rokidi, S; Zandieh, S; Behunova, J; Muschitz, C; Fahrleitner-Pammer, A; Ng, AYJ; Tohari, S; Venkatesh, B; Bonnard, C; Reversade, B; Klaushofer, K; Al Kaissi, A;
Bone. 2019; 123: 48-55.
Fallberichte

Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression.
Timaru-Kast, R; Gotthardt, P; Luh, C; Huang, C; Hummel, R; Schäfer, MKE; Thal, SC;
Front Aging Neurosci. 2019; 11:63
Originalarbeiten (Zeitschrift)

Glycine Induces Migration of Microglial BV-2 Cells via SNAT-Mediated Cell Swelling.
Kittl, M; Dobias, H; Beyreis, M; Kiesslich, T; Mayr, C; Gaisberger, M; Ritter, M; Kerschbaum, HH; Jakab, M;
Cell Physiol Biochem. 2018; 50(4): 1460-1473.
Originalarbeiten (Zeitschrift)

Age Influences Microglial Activation After Cuprizone-Induced Demyelination.
Klein, B; Mrowetz, H; Barker, CM; Lange, S; Rivera, FJ; Aigner, L
FRONT AGING NEUROSCI. 2018; 10: 278
Originalarbeiten (Zeitschrift)

Bioluminescence imaging visualizes osteopontin-induced neurogenesis and neuroblast migration in the mouse brain after stroke
Rogall, R; Rabenstein, M; Vay, S; Bach, A; Pikhovych, A; Baermann, J; Hoehn, M; Couillard-Despres, S; Fink, GR; Schroeter, M; Rueger, MA
STEM CELL RES THER. 2018; 9: 182
Originalarbeiten (Zeitschrift)

Macrophage CD163 expression in cerebrospinal fluid: association with subarachnoid hemorrhage outcome.
Thomas, AJ; Ogilvy, CS; Griessenauer, CJ; Hanafy, KA;
J Neurosurg. 2018; 131(1):47-53
Originalarbeiten (Zeitschrift)

Lymphatic markers in the human optic nerve.
Trost, A; Runge, C; Bruckner, D; Kaser-Eichberger, A; Bogner, B; Strohmaier, C; Reitsamer, HA; Schroedl, F;
Exp Eye Res. 2018; 173: 113-120.
Originalarbeiten (Zeitschrift)

Doublecortin expression in CD8+ T-cells and microglia at sites of amyloid-β plaques: A potential role in shaping plaque pathology?
Unger, MS; Marschallinger, J; Kaindl, J; Klein, B; Johnson, M; Khundakar, AA; Roßner, S; Heneka, MT; Couillard-Despres, S; Rockenstein, E; Masliah, E; Attems, J; Aigner, L;
Alzheimers Dement. 2018; 14(8): 1022-1037.
Originalarbeiten (Zeitschrift)

Microglia prevent peripheral immune cell invasion and promote an anti-inflammatory environment in the brain of APP-PS1 transgenic mice.
Unger, MS; Schernthaner, P; Marschallinger, J; Mrowetz, H; Aigner, L
J NEUROINFLAMM. 2018; 15(1): 274
Originalarbeiten (Zeitschrift)

Identification of new molecular targets for PET imaging of the microglial anti-inflammatory activation state
Villa, A; Klein, B; Janssen, B; Pedragosa, J; Pepe, G; Zinnhardt, B; Vugts, DJ; Gelosa, P; Sironi, L; Beaino, W; Damont, A; Dolle, F; Jego, B; Winkeler, A; Ory, D; Solin, O; Vercouillie, J; Funke, U; Laner-Plamberger, S; Blomster, LV; Christophersen, P; Vegeto, E; Aigner, L; Jacobs, A; Planas, AM; Maggi, A; Windhorst, AD
THERANOSTICS. 2018; 8(19): 5400-5418.
Originalarbeiten (Zeitschrift)

Lymphatic and vascular markers in an optic nerve crush model in rat.
Trost, A; Bruckner, D; Kaser-Eichberger, A; Motloch, K; Bogner, B; Runge, C; Strohmaier, C; Couillard-Despres, S; Reitsamer, HA; Schroedl, F;
Exp Eye Res. 2017; 159:30-39
Originalarbeiten (Zeitschrift)

Interleukin-4 is a participant in the regulation of depressive-like behavior.
Wachholz, S; Knorr, A; Mengert, L; Plumper, J; Sommer, R; Juckel, G; Friebe, A
BEHAV BRAIN RES. 2017; 326: 165-172.
Originalarbeiten (Zeitschrift)

Schizophrenia associated sensory gating deficits develop after adolescent microglia activation.
Eßlinger, M; Wachholz, S; Manitz, MP; Plümper, J; Sommer, R; Juckel, G; Friebe, A;
Brain Behav Immun. 2016; 58: 99-106.
Originalarbeiten (Zeitschrift)

MIF-CD74 signaling impedes microglial M1 polarization and facilitates brain tumorigenesis.
Ghoochani, A; Schwarz, MA; Yakubov, E; Engelhorn, T; Doerfler, A; Buchfelder, M; Bucala, R; Savaskan, NE; Eyüpoglu, IY;
Oncogene. 2016; 35(48):624-6261
Originalarbeiten (Zeitschrift)

A versatile ex vivo technique for assaying tumor angiogenesis and microglia in the brain.
Ghoochani, A; Yakubov, E; Sehm, T; Fan, Z; Hock, S; Buchfelder, M; Eyüpoglu, IY; Savaskan, NE;
Oncotarget. 2016; 7(2):1838-1853
Originalarbeiten (Zeitschrift)

Expression of Lymphatic Markers in the Adult Rat Spinal Cord.
Kaser-Eichberger, A; Schroedl, F; Bieler, L; Trost, A; Bogner, B; Runge, C; Tempfer, H; Zaunmair, P; Kreutzer, C; Traweger, A; Reitsamer, HA; Couillard-Despres, S;
Front Cell Neurosci. 2016; 10: 23
Originalarbeiten (Zeitschrift)

Allergy Enhances Neurogenesis and Modulates Microglial Activation in the Hippocampus.
Klein, B; Mrowetz, H; Thalhamer, J; Scheiblhofer, S; Weiss, R; Aigner, L;
Front Cell Neurosci. 2016; 10: 169
Originalarbeiten (Zeitschrift)

In vitro toxicity of the galanin receptor 3 antagonist SNAP 37889.
Koller, A; Rid, R; Beyreis, M; Bianchini, R; Holub, BS; Lang, A; Locker, F; Brodowicz, B; Velickovic, O; Jakab, M; Kerschbaum, H; Önder, K; Kofler, B;
Neuropeptides. 2016; 56:83-88
Originalarbeiten (Zeitschrift)

Telomere shortening leads to earlier age of onset in ALS mice.
Linkus, B; Wiesner, D; Messner, M; Karabatsiakis, A; Scheffold, A; Rudolph, KL; Thal, DR; Weishaupt, JH; Ludolph, AC; Danzer, KM
Aging (Albany NY). 2016; 8(2):382-393
Originalarbeiten (Zeitschrift)

Flow cytometric characterization of microglia in the offspring of PolyI:C treated mice.
Manitz, MP; Plümper, J; Demir, S; Ahrens, M; Eßlinger, M; Wachholz, S; Eisenacher, M; Juckel, G; Friebe, A;
Brain Res. 2016; 1636:17-82
Originalarbeiten (Zeitschrift)

Microglia activation is associated with IFN-α induced depressive-like behavior.
Wachholz, S; Eßlinger, M; Plümper, J; Manitz, MP; Juckel, G; Friebe, A;
Brain Behav Immun. 2016; 55:105-113
Originalarbeiten (Zeitschrift)

Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages.
Choi, J; Stradmann-Bellinghausen, B; Yakubov, E; Savaskan, NE; Régnier-Vigouroux, A;
Cancer Biol Ther. 2015; 16(8):1205-1213
Originalarbeiten (Zeitschrift)

Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9.
Lindner, M; Thümmler, K; Arthur, A; Brunner, S; Elliott, C; McElroy, D; Mohan, H; Williams, A; Edgar, JM; Schuh, C; Stadelmann, C; Barnett, SC; Lassmann, H; Mücklisch, S; Mudaliar, M; Schaeren-Wiemers, N; Meinl, E; Linington, C;
Brain. 2015; 138(Pt 7): 1875-1893.
Originalarbeiten (Zeitschrift)

Galanin modulates human and murine neutrophil activation in vitro.
Locker, F; Lang, AA; Koller, A; Lang, R; Bianchini, R; Kofler, B;
Acta Physiol (Oxf). 2015; 213(3):595-602
Originalarbeiten (Zeitschrift)

Time-dependent retinal ganglion cell loss, microglial activation and blood-retina-barrier tightness in an acute model of ocular hypertension.
Trost, A; Motloch, K; Bruckner, D; Schroedl, F; Bogner, B; Kaser-Eichberger, A; Runge, C; Strohmaier, C; Klein, B; Aigner, L; Reitsamer, HA;
Exp Eye Res. 2015; 136:59-71
Originalarbeiten (Zeitschrift)

From the nucleus to the plasma membrane: translocation of the nuclear proteins histone H3 and lamin B1 in apoptotic microglia.
Klein, B; Lütz-Meindl, U; Kerschbaum, HH;
Apoptosis. 2014; 19(5): 759-775.
Originalarbeiten (Zeitschrift)

Glycine modulates membrane potential, cell volume, and phagocytosis in murine microglia.
Komm, B; Beyreis, M; Kittl, M; Jakab, M; Ritter, M; Kerschbaum, HH;
Amino Acids. 2014; 46(8): 1907-1917.
Originalarbeiten (Zeitschrift)

Hippocampal neurogenesis and antidepressive therapy: shocking relations.
Rotheneichner, P; Lange, S; OSullivan, A; Marschallinger, J; Zaunmair, P; Geretsegger, C; Aigner, L; Couillard-Despres, S;
Neural Plast. 2014; 2014:723915
Übersichtsarbeiten

Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models.
Schuh, C; Wimmer, I; Hametner, S; Haider, L; Van Dam, AM; Liblau, RS; Smith, KJ; Probert, L; Binder, CJ; Bauer, J; Bradl, M; Mahad, D; Lassmann, H;
Acta Neuropathol. 2014; 128(2): 247-266.
Originalarbeiten (Zeitschrift)

Chloride channel blockers suppress formation of engulfment pseudopodia in microglial cells.
Harl, B; Schmölzer, J; Jakab, M; Ritter, M; Kerschbaum, HH;
Cell Physiol Biochem. 2013; 31(2-3):319-337
Originalarbeiten (Zeitschrift)

Noninvasive molecular imaging of neuroinflammation.
Jacobs, AH; Tavitian, B;
J Cereb Blood Flow Metab. 2012; 32(7):1393-1415
Übersichtsarbeiten

Microglial activation in a neuroinflammational animal model of schizophrenia--a pilot study.
Juckel, G; Manitz, MP; Brüne, M; Friebe, A; Heneka, MT; Wolf, RJ;
Schizophr Res. 2011; 131(1-3):96-100
Originalarbeiten (Zeitschrift)

Perturbation of intracellular K(+) homeostasis with valinomycin promotes cell death by mitochondrial swelling and autophagic processes.
Klein, B; Wörndl, K; Lütz-Meindl, U; Kerschbaum, HH;
Apoptosis. 2011; 16(11): 110-117.
Originalarbeiten (Zeitschrift)

ADAM12 is expressed by astrocytes during experimental demyelination.
Baertling, F; Kokozidou, M; Pufe, T; Clarner, T; Windoffer, R; Wruck, CJ; Brandenburg, LO; Beyer, C; Kipp, M;
Brain Res. 2010; 1326:1-14
Originalarbeiten (Zeitschrift)

Application of the ELISPOT method for comparative analysis of interleukin (IL)-6 and IL-10 secretion in peripheral blood of patients with astroglial tumors.
Samaras, V; Piperi, C; Korkolopoulou, P; Zisakis, A; Levidou, G; Themistocleous, MS; Boviatsis, EI; Sakas, DE; Lea, RW; Kalofoutis, A; Patsouris, E;
Mol Cell Biochem. 2007; 304(1-2):343-351
Originalarbeiten (Zeitschrift)

Progesterone and its metabolites 5-dihydroprogesterone and 5-3-tetrahydroprogesterone decrease LPS-induced NO release in the murine microglial cell line, BV-2.
Müller, E; Kerschbaum, HH;
Neuro Endocrinol Lett. 2006; 27(5):675-678
Originalarbeiten (Zeitschrift)

Ultraviolet irradiation-induced apoptosis does not trigger nuclear fragmentation but translocation of chromatin from nucleus into cytoplasm in the microglial cell-line, BV-2.
Zierler, S; Klein, B; Furtner, T; Bresgen, N; Lütz-Meindl, U; Kerschbaum, HH;
Brain Res. 2006; 1121(1):12-21
Originalarbeiten (Zeitschrift)

In search of the astrocytic factor(s) modulating blood-brain barrier functions in brain capillary endothelial cells in vitro.
Haseloff, RF; Blasig, IE; Bauer, HC; Bauer, H;
Cell Mol Neurobiol. 2005; 25(1): 25-39.
Übersichtsarbeiten

The LPS receptor (CD14) links innate immunity with Alzheimer"s disease.
Fassbender, K; Walter, S; Kühl, S; Landmann, R; Ishii, K; Bertsch, T; Stalder, AK; Muehlhauser, F; Liu, Y; Ulmer, AJ; Rivest, S; Lentschat, A; Gulbins, E; Jucker, M; Staufenbiel, M; Brechtel, K; Walter, J; Multhaup, G; Penke, B; Adachi, Y; Hartmann, T; Beyreuther, K;
FASEB J. 2004; 18(1):203-205
Originalarbeiten (Zeitschrift)