Research Database PMU-SQQUID

PMU-Authors

Abstract

The anti-inflammatory potential of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, as reflected by modulation of C-reactive protein (CRP), might be beneficial in the treatment of patients with multiple sclerosis (MS). We evaluated serum levels of high-sensitivity (hs)-CRP in relapsing-remitting MS patients receiving interferon-beta 1b and atorvastatin as add-on therapy. This study shows that interferon-beta treatment is associated with increased serum levels of hs-CRP in MS patients (P<0.01). In contrast, when atorvastatin is added to interferon-beta, hs-CRP serum levels decrease to the normal range (P<0.05), indicating an anti-inflammatory action of atorvastatin in MS. However, whether add-on treatment with atorvastatin modifies the course of MS remains to be investigated.

Useful keywords (using NLM MeSH Indexing)

Adjuvants, Immunologic/administration*

dosage

Adolescent

Adult

Atorvastatin Calcium

Biomarkers/blood

C-Reactive Protein/metabolism*

Drug Interactions

Drug Therapy, Combination

Heptanoic Acids/administration*

dosage*

Humans

Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration*

dosage*

Interferon beta-1b

Interferon-beta/administration*

dosage

Middle Aged

Multiple Sclerosis, Relapsing-Remitting/drug therapy*

Multiple Sclerosis, Relapsing-Remitting/immunology*

Pyrroles/administration*

dosage*

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