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Research Database PMU-SQQUID

Phenotypic characterization and preclinical production of human lineage-negative cells for regenerative stem cell therapy.
Strunk, D; Rohde, E; Lanzer, G; Linkesch, W
Transfusion. 2005; 45(3):315-326
Originalarbeiten (Zeitschrift)

PMU-Authors

Rohde Eva
Strunk Dirk

Abstract

Regenerative stem cell therapy (SCT) is currently being tested in clinical trials. The ideal type and source of cells have not yet been defined. Lineage (Lin) depletion is an experimental procedure capable of enriching all recently recognized SC types with regenerative potency. This study was performed to define a practicable monoclonal antibody (MoAb) cocktail for Lin depletion and to test whether clinical-scale Lin depletion is possible.


Useful keywords (using NLM MeSH Indexing)

Adult

Antibodies, Monoclonal/immunology*

Biomarkers

Cell Lineage/immunology*

Cell Separation/methods

Female

Flow Cytometry/methods*

Fluorescent Antibody Technique

Hematopoietic Stem Cell Transplantation*

Hematopoietic Stem Cells/cytology*

Hematopoietic Stem Cells/immunology

Humans

Immunophenotyping

Leukapheresis/methods

Male

Membrane Proteins/immunology

Middle Aged