' '
Deutsch | English    

Research Database PMU-SQQUID

Motor cortex excitability in transient global amnesia.
Nardone, R; Buffone, EC; Matullo, MF; Tezzon, F
J NEUROL. 2004; 251(1): 42-46.
Full papers/articles (Journal)


Nardone Raffaele


Objective To investigate the physiology of motor cortical areas in patients with transient global amnesia (TGA). Materials and methods We performed transcranial magnetic stimulation (TMS) and single photon emission computed tomography (SPECT) in 13 patients during and after the acute phase of a typical episode of TGA. Measures of cortical excitability included motor threshold (MT) to magnetic stimulation, cortical silent period (SP) duration and intracortical inhibition (ICI) using a paired-pulse TMS technique. Results We found thalamic hypoperfusion and an ipsilateral significantly decreased ICI during the acute phase of TGA. Conclusions Reduced activity in inhibitory circuits may explain why PET studies of patients with TGA showed neocortical hypometabolism. Our findings are consistent with the hypothesis that frontal cortex dysfunction probably due to damage affecting the thalamocortical circuits may play an important role in the pathogenesis of the syndrome.

Useful keywords (using NLM MeSH Indexing)



Amnesia, Transient Global/physiopathology*

Analysis of Variance

Case-Control Studies

Electric Stimulation/methods


Functional Laterality/physiology




Middle Aged

Motor Cortex/physiopathology*

Motor Cortex/radiation effects

Neural Conduction/physiology

Neural Inhibition/physiology

Neuropsychological Tests

Reaction Time

Sensory Thresholds/drug effects

Sensory Thresholds/physiology

Time Factors

Tomography, Emission-Computed, Single-Photon/methods

Find related publications in this database (Keywords)

transient global amnesia
transcranial magnetic stimulation