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Research Database PMU-SQQUID

The trigemino-cervical reflex in patients with trigeminal neuralgia.
Nardone, R; Matullo, MF; Tezzon, F
NEUROL RES. 2005; 27(1): 36-40.
Full papers/articles (Journal)


Nardone Raffaele


Objectives: To investigate the central trigeminal system in idiopathic trigeminal neuralgia (TN). Materials and method: Short latency responses can be recorded in sternocleidomastoid (SCM) muscles after stimulation of the trigeminal nerve (trigemino-cervical reflex). This brainstem reflex was investigated in 40 healthy subjects and in 17 patients suffering from idiopathic TN before and after therapy for 2 months carbamazepin. Results: Before therapy, six patients presented abnormalities of SCM responses on the painful side, six patients with bilateral abnormalities, and five patients with normal responses. A significant variation in the responses after therapy was found only in the patients with unilateral abnormalities: these patients and the patients with normal reflexes be)ore therapy also had a good response to the therapy with significant pain relief. Conclusions: Our findings suggest that the trigemino-cervical reflex could be useful in the clinical assessment of TN prior to instituting non-surgical treatment. The bilateral location of the abnormalities in some patients seems to point to a centrally located dysfunction, therefore, this study supports the idea that mechanisms in the central nervous system may play an important role in the pathophysiology of trigeminal neuralgic pain.

Useful keywords (using NLM MeSH Indexing)


Anticonvulsants/therapeutic use

Carbamazepine/therapeutic use

Electric Stimulation/methods



Functional Laterality



Neck Muscles/drug effects

Neck Muscles/innervation

Neck Muscles/physiopathology*

Reaction Time/drug effects

Reaction Time/physiology

Reaction Time/radiation effects

Reflex/drug effects


Reflex/radiation effects

Trigeminal Nerve Diseases/physiopathology*

Trigeminal Neuralgia/drug therapy

Trigeminal Neuralgia/physiopathology*

Find related publications in this database (Keywords)

trigeminal neuralgia
trigemino-cervical reflex