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Research Database PMU-SQQUID

Molecular biological analysis of the heterogeneous prostate cancer group Gleason score 7.
Mian, C; Lodde, M; Comploj, E; Palermo, S; Lusuardi, L; Marziani, F; Chiocchetti, A; Spada, A; Mian, M; Pycha, A;
Prostate. 2006; 66(9): 966-970.
Originalarbeiten (Zeitschrift)

PMU-Authors

Lusuardi Lukas

Abstract

BACKGROUND. On the basis of a multicolor-FISH test we aimed, at verifying whether there is any molecular biological background for the different behavior of Gleason Score 7 prostate cancer (PCa). PATIENTS AND METHODS. Biopsies of 44 patients with histological verified PCa, 20 with Gleason score 3 + 4 (group A) and 24 with 4 + 3 (group B), were analyzed using FISH. RESULTS. In group A, FISH detected a unique gain of 8q24 in 2 patients (10.0%) and a unique loss of 8p22 in 9 patients (45.0%). No concurrent loss and gain of both sites were found in this group. Of group B (4 + 3) a unique loss of Sp22 was observed in 14 patients (58.3%) and a concurrent loss of 8p22 and gain of 8q24 in 6 patients (25.0%). CONCLUSION. Different molecular genetic patterns could explain the different biological behavior of the 2 groups. The analysis of chromosomal aberrations could therefore influence the clinical decision process in the future.


Useful keywords (using NLM MeSH Indexing)

Aged

Aged, 80 and over

Biopsy

Chromosome Aberrations

Chromosomes, Human, Pair 8/genetics

DNA, Neoplasm/analysis

DNA, Neoplasm/genetics

Disease Progression

Genetic Heterogeneity*

Humans

In Situ Hybridization, Fluorescence

Male

Middle Aged

Neoplasm Staging*

Prognosis

Prostatic Neoplasms/genetics*

Prostatic Neoplasms/pathology*

Severity of Illness Index


Find related publications in this database (Keywords)

prostate cancer
fluorescence
chromosomes
biological behavior