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Research Database PMU-SQQUID

Molecular biological analysis of the heterogeneous prostate cancer group Gleason score 7.
Mian, C; Lodde, M; Comploj, E; Palermo, S; Lusuardi, L; Marziani, F; Chiocchetti, A; Spada, A; Mian, M; Pycha, A;
Prostate. 2006; 66(9): 966-970.
Originalarbeiten (Zeitschrift)


Lusuardi Lukas


BACKGROUND. On the basis of a multicolor-FISH test we aimed, at verifying whether there is any molecular biological background for the different behavior of Gleason Score 7 prostate cancer (PCa). PATIENTS AND METHODS. Biopsies of 44 patients with histological verified PCa, 20 with Gleason score 3 + 4 (group A) and 24 with 4 + 3 (group B), were analyzed using FISH. RESULTS. In group A, FISH detected a unique gain of 8q24 in 2 patients (10.0%) and a unique loss of 8p22 in 9 patients (45.0%). No concurrent loss and gain of both sites were found in this group. Of group B (4 + 3) a unique loss of Sp22 was observed in 14 patients (58.3%) and a concurrent loss of 8p22 and gain of 8q24 in 6 patients (25.0%). CONCLUSION. Different molecular genetic patterns could explain the different biological behavior of the 2 groups. The analysis of chromosomal aberrations could therefore influence the clinical decision process in the future.

Useful keywords (using NLM MeSH Indexing)


Aged, 80 and over


Chromosome Aberrations

Chromosomes, Human, Pair 8/genetics

DNA, Neoplasm/analysis

DNA, Neoplasm/genetics

Disease Progression

Genetic Heterogeneity*


In Situ Hybridization, Fluorescence


Middle Aged

Neoplasm Staging*


Prostatic Neoplasms/genetics*

Prostatic Neoplasms/pathology*

Severity of Illness Index

Find related publications in this database (Keywords)

prostate cancer
biological behavior