Research Database PMU-SQQUID

PMU-Authors

Abstract

Seventy patients with multiple sclerosis (according to Poser"s criteria) were clinically assessed and examined with MRI, multimodal evoked potentials (VEP, AEP, SSEP) and CSF analysis (transformed lymphocytes, IgG-Index, oligoclonal banding). In relation to the clinical criteria of McAlpine 40 patients had possible, 16 patients probable and 14 patients definite MS. 81% of the patients (73% possible MS, 94% probable MS, 93% definite MS) had multiple white matter lesions detected by MRI, 79% (78% possible MS, 94% probable MS, 64% definite MS) had an abnormal CSF profile and 67% (60% possible MS, 75% probable MS, 79% definite MS) abnormal results in multimodal EP testing. Of the patients who experienced only one attack (n = 40) 78% had multiple lesions on MRI, 88% had abnormal CSF-findings and 60% had pathologic EPs. Patients with two or more attacks showed in 87% multiple lesions on MRI, in 77% abnormal EPs and in 70% abnormal CSF findings. The number of abnormal MRI and EPs increases with the duration of the disease. 13 patients with a normal MRI were discussed separately. MRI is the most sensitive method in detecting the spatial pattern of disseminated lesions. To monitor the dissemination over time a careful clinical follow-up is still mandatory.

Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Arousal/physiology*

Attention/physiology*

Brain/pathology

Brain/physiopathology

Brain Stem/pathology

Brain Stem/physiopathology

Diagnosis, Differential

Electroencephalography*

Evoked Potentials/physiology

Evoked Potentials, Auditory, Brain Stem/physiology

Female

Humans

Immunoglobulin G/cerebrospinal fluid*

Immunoglobulins/cerebrospinal fluid*

Lymphocyte Activation/immunology*

Magnetic Resonance Imaging*

Male

Middle Aged

Multiple Sclerosis/diagnosis*

Multiple Sclerosis/physiopathology

Neurologic Examination

Oligoclonal Bands

Reaction Time/physiology

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