The release of reactive oxygen species (ROS) by mitochondria instigates the pathways of programmed cell death in eukaryotic cells. Gourlay and Ayscough present intriguing experimental evidence that mutations in the genes encoding the regulatory proteins End3p and Sla1p, which influence actin dynamics in budding yeast, lead to a loss of mitochondrial membrane potential, resulting in ROS production and apoptosis. This effect can be suppressed by down-regulation of the RAS-cAMP signaling pathway, thus establishing the existence of a new and complex regulatory network.
Useful keywords (using NLM MeSH Indexing)
Gene Expression Regulation, Fungal
Reactive Oxygen Species/metabolism*
Saccharomyces cerevisiae Proteins/genetics
Saccharomyces cerevisiae Proteins/physiology