A sequence motif of about 100 amino acids, termed the xxxcalponin homology domainxxx has been suggested to confer actin binding to a variety of cytoskeletal and signalling molecules, Here we analyse and compare the sequences of all calponin homology domain-containing proteins identified to date. We propose that single calponin homology domains do not confer actin-binding per se and that the actin-binding motifs of crosslinking proteins, which comprise two disparate calponin homology domains, represent a unique protein module, (C) 1998 Federation of European Biochemical Societies.
Useful keywords (using NLM MeSH Indexing)
Amino Acid Sequence
Molecular Sequence Data
Sequence Homology, Amino Acid
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