' '
Deutsch | English    

Research Database PMU-SQQUID

Mammalian calponin. Identification and expression of genetic variants.
Strasser, P; Gimona, M; Moessler, H; Herzog, M; Small, JV;
FEBS Lett. 1993; 330(1):13-18
Originalarbeiten (Zeitschrift)

PMU-Authors

Gimona Mario
Strasser Peter

Abstract

Calponin is a smooth muscle specific, actin-, tropomyosin- and calmodulin-binding protein thought to be involved in some way in the regulation or modulation of contraction. Here we describe the cloning and bacterial expression of two calponin species from murine and porcine smooth muscle tissues. Primary and secondary structural analyses of the deduced amino acid sequences revealed a high degree of homology to avian calponin with the exception of a short and variable C-terminal segment. The sequence data demonstrate that the two mammalian calponin variants do not arise via alternative splicing but are encoded by different genes.


Useful keywords (using NLM MeSH Indexing)

Amino Acid Sequence

Animals

Blotting, Western

Calcium-Binding Proteins/chemistry

Calcium-Binding Proteins/genetics*

Chickens

DNA

Electrophoresis, Gel, Two-Dimensional

Genetic Variation

Mice

Microfilament Proteins

Molecular Sequence Data

Muscle Proteins/chemistry

Muscle Proteins/genetics*

Muscle, Smooth/metabolism

RNA, Messenger/genetics

RNA, Messenger/metabolism

Rats

Sequence Homology, Amino Acid

Swine


Find related publications in this database (Keywords)

SMOOTH MUSCLE
CALPONIN
ACTIN-BINDING PROTEIN
BACTERIAL EXPRESSION