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Research Database PMU-SQQUID

Follicle-stimulating hormone activates a cAMP-dependent chloride conductance in TM4 Sertoli cells.
Jungwirth, A; Weiger, T; Singh, SK; Paulmichl, M; Frick, J;
Biochem Biophys Res Commun. 1997; 233(1): 203-206.
Originalarbeiten (Zeitschrift)


Paulmichl Markus


The effect of follicle-stimulating hormone (FSH) on the electrical properties of TM4-Sertoli cells was investigated. Addition of 5 IU/ml FSH caused a dose-dependent and reversible depolarization of the resting membrane potential by +15.3 +/- 1.0 mV accompanied by a decrease of the input resistance. The depolarization was completely abolished in chloride-free solutions. The reversal potential of the effect was close to the calculated reversal potential for chloride. We conclude that FSH activates a chloride conductance in cultured TM4 Sertoli cells.

Useful keywords (using NLM MeSH Indexing)


Cyclic AMP/metabolism*

Follicle Stimulating Hormone/pharmacology*


Membrane Potentials/drug effects


Mice, Inbred BALB C

Sertoli Cells/drug effects*

Sertoli Cells/metabolism

Sertoli Cells/physiology