Research Database PMU-SQQUID

Selection of Tissue Factor-Deficient Cell Transplants as a Novel Strategy for Improving Hemocompatibility of Human Bone Marrow Stromal Cells
Oeller, M; Laner-Plamberger, S; Hochmann, S; Ketterl, N; Feichtner, M; Brachtl, G; Hochreiter, A; Scharler, C; Bieler, L; Romanelli, P; Couillard-Despres, S; Russe, E; Schallmoser, K; Strunk, D
THERANOSTICS. 2018; 8(5): 1421-1434.
Full papers/articles (Journal)

Abstract/Keywords Web of Science PubMed PUBMED Central Full Text

PMU-Authors

Bieler Lara Sophie
Brachtl Gabriele
Couillard-Després Sébastien
Feichtner Martina
Hochmann Sarah
Hoog Anna
Ketterl Nina
Laner-Plamberger Sandra
Öller Michaela
Romanelli Pasquale
Russe Elisabeth
Schallmoser Katharina
Scharler Cornelia
Strunk Dirk

Abstract

Intravascular transplantation of tissue factor (TF)-bearing cells elicits an instant blood-mediated inflammatory reaction (IBMIR) resulting in thrombotic complications and reduced engraftment. Here we studied the hemocompatibility of commonly used human white adipose tissue (WAT), umbilical cord (UC) and bone marrow stromal cells (BMSC) and devised a possible strategy for safe and efficient stromal cell transplantation.

Find related publications in this database (Keywords)

Cell transplantation
instant blood-mediated inflammatory reaction (IBMIR)
tissue factor (TF)
bone marrow stromal cells (BMSC)
endothelial colony-forming progenitor cells (ECFC)
human platelet lysate (HPL)