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Research Database PMU-SQQUID

Peptidergic innervation of the human clitoris.
Hauser-Kronberger, C; Cheung, A; Hacker, GW; Graf, AH; Dietze, O; Frick, J;
PEPTIDES. 1999; 20(5): 539-543.
Originalarbeiten (Zeitschrift)

PMU-Authors

Dietze Otto
Kronberger Cornelia

Abstract


In the present study, the distributions of neuropeptides in the normal human clitoris and in a clitoris from an adrenogenital syndrome (AGS) was demonstrated by immunohistochemistry (IHC). Immunohistochemical screening detected a complex network of nerve fibers containing vasoactive intestinal polypeptide (VIP), peptide histidine methionine (PHM), neuropeptide tyrosine (neuropeptide Y), C-flanking peptide of neuropeptide Y (CPON), calcitonin gene-related peptide (CGRP) and substance P immunoreactivities. Special attention was given to the VIP-related peptide helospectin, that has been detected in neuronal elements in the clitoris. No visible differences between the localization and distribution of peptidergic nerve fibers of normal and hypertrophic clitoris from AGS have been observed. Co-localization studies showed the co-existence of VIP, PHM and partly helospectin and neuropeptide Y with CPON within nerve fibers in the cavernous tissue and substance P and CGRP co-expression in nerve fibers especially underneath and within the glans clitoris.


Useful keywords (using NLM MeSH Indexing)

Adrenal Hyperplasia, Congenital/pathology

Blood Vessels/innervation

Clitoris/innervation*

Female

Humans

Nerve Net

Neuropeptides/isolation*

purification*

Vasoconstrictor Agents/isolation*

purification

Vasodilator Agents/isolation*

purification


Find related publications in this database (Keywords)

clitoris
adrenogenital syndrome
immunohistochemistry
vasoactive intestinal polypeptide (VIP)
helospectin
neuropeptide tyrosine (neuropeptide Y)
substance P
calcitonin gene-related peptide (CGRP)