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Necrotizing soft tissue infections after injection therapy: Higher mortality and worse outcome compared to other entry mechanisms.
Friederichs, J; Torka, S; Militz, M; Bühren, V; Hungerer, S;
J Infect. 2015; 71(3):312-316
Full papers/articles (Journal)


Bühren Volker
Hungerer Sven


Necrotizing Soft Tissue Infections represent a rare entity of infection associated with a high mortality. The aim of this retrospective study was to analyze patients with an iatrogenic etiology of injection or infiltration to compare the outcome with other etiologies.
The study group consisted of 21 patients treated with a Necrotizing Fasciitis caused by injection or infiltration. Risk factors and outcome were compared to 134 patients with a Necrotizing Fasciitis caused by other entry mechanisms.
Overall mortality in our study group was 14 of 21 (67%) with an amputation rate of 11 of 15 (73%) if an extremity was involved. The survival rate was significantly worse after injection or infiltration (p < 0.001) as was the amputation rate (p = 0.013), the percentage of patients requiring intensive care (100% vs. 83%, p = 0.038) and vasopressors (81% vs. 54%, p = 0.02). Injection or infiltration therapy proved to be the strongest prognostic factor (p = 0.003) besides the known risk factors obesity (0.007) and renal insufficiency (0.025).
Our results demonstrate that patients with a Necrotizing Soft Tissue Infection after injection or infiltration therapy have a significantly worse prognosis.

Useful keywords (using NLM MeSH Indexing)



Aged, 80 and over


numerical data

Fasciitis, Necrotizing/etiology*

Fasciitis, Necrotizing/microbiology

Fasciitis, Necrotizing/mortality*

Fasciitis, Necrotizing/therapy



Injections/adverse effects*


Middle Aged

Retrospective Studies

Risk Factors

Soft Tissue Infections/etiology*

Soft Tissue Infections/microbiology

Soft Tissue Infections/mortality*

Soft Tissue Infections/therapy

Survival Rate

Treatment Outcome

Find related publications in this database (Keywords)

Necrotizing soft tissue infection
Necrotizing fasciitis
Injection therapy