The interplay between Candida species and pattern recognition receptors, interleukins, kynurenine, and T cells has been studied in murine and ex vivo human studies, but data are lacking from patients with invasive fungal infections. Interleukin 17A (IL-17A) is considered an important component in host defense against Candida infections and is modulated by Candida-induced impairment of tryptophan-kynurenine metabolism.
Useful keywords (using NLM MeSH Indexing)
Aged, 80 and over
Intensive Care Units
Toll-Like Receptor 2/metabolism
Toll-Like Receptor 4/metabolism
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