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Research Database PMU-SQQUID

Decrease of mitochondrial DNA content and energy metabolism in renal cell carcinoma.
Meierhofer, D; Mayr, JA; Foetschl, U; Berger, A; Fink, K; Schmeller, N; Hacker, GW; Hauser-Kronberger, C; Kofler, B; Sperl, W;
CARCINOGENESIS. 2004; 25(6): 1005-1010.
Originalarbeiten (Zeitschrift)

PMU-Authors

Kofler Barbara
Kronberger Cornelia
Mayr Johannes A.
Sperl Wolfgang

Abstract

To elucidate the relationship between tumorgenesis and the mitochondrial energy metabolism in renal neoplasms, we studied three individual enzyme activities of the oxidative phosphorylation, two components of the Krebs cycle and the mitochondrial DNA content of renal carcinomas including 29 conventional, five papillary, two unclassified carcinomas with sarcomatoid features and one collecting duct carcinoma. A significant reduction of all mitochondrial enzyme activities including complex V, as well as of the mitochondrial DNA content was detected in 34 of 37 renal carcinoma tissues as compared with control kidney. Mitochondrial enzyme activities and mitochondrial DNA levels were not statistically different between the conventional, papillary and unclassified sarcomatoid type of renal carcinoma and did not correlate with tumour grade, metastasis, ploidy and proliferative activity as determined by Ki-67 staining. Taken together, our data indicate that a co-ordinated down-regulation of all components necessary for mitochondrial energy metabolism occurs in most renal carcinomas as an early event in carcinoma formation, which does not change with progression of the disease.


Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Aged, 80 and over

Blotting, Western

Carcinoma, Renal Cell/metabolism*

DNA, Mitochondrial/metabolism*

Energy Metabolism

Female

Humans

Immunohistochemistry

Kidney Neoplasms/metabolism*

Male

Middle Aged