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Research Database PMU-SQQUID

The influence of topical dermatological treatment modalities on epidermal Langerhans cells and contact sensitization in mice.
GRUNER, S; ZWIRNER, A; STRUNK, D; SONNICHSEN, N
Contact Dermatitis. 1992; 26(4):241-247
Originalarbeiten (Zeitschrift)

PMU-Authors

Strunk Dirk

Abstract

The influence of the widely used topical dermatological treatment modalities anthralin, coal tar and pyrogallol on surface markers of epidermal Langerhans cells and contact sensitization was studied and compared with that of a PUVA treatment. A common effect of all dermatological therapies tested was inhibition of Langerhans cell ATPase, whereas an effect on MHC class II antigens was found only after PUVA or tar treatment. The induction of contact hypersensitivity was inhibited only by PUVA, and not by the other treatments. These results show that various forms of topical therapy influence surface markers and immunological function of epidermal Langerhans cells differently.


Useful keywords (using NLM MeSH Indexing)

Adenosine Triphosphatases/drug effects*

Adenosine Triphosphatases/metabolism

Administration, Topical

Animals

Anthralin/administration*

dosage

Anthralin/therapeutic use

Coal Tar/administration*

dosage

Coal Tar/therapeutic use

Dermatitis, Contact/drug therapy*

Dermatitis, Contact/metabolism

Histocompatibility Antigens Class II/drug effects*

Histocompatibility Antigens Class II/metabolism

Langerhans Cells/drug effects*

Langerhans Cells/metabolism

Mice

Mice, Inbred BALB C

PUVA Therapy*

Pyrogallol/administration*

dosage

Pyrogallol/therapeutic use

Time Factors


Find related publications in this database (Keywords)

ULTRAVIOLET LIGHT
ANTHRALIN
COAL TAR
PYROGALLOL
LANGERHANS CELLS
SURFACE ANTIGENS
CONTACT SENSITIZATION
IMMUNOLOGICAL BASIS