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Facilitated neurogenic inflammation in unaffected limbs of patients with complex regional pain syndrome.
Leis, S; Weber, M; Schmelz, M; Birklein, F;
Neurosci Lett. 2004; 359(3):163-166
Originalarbeiten (Zeitschrift)


Leis Stefan


Pain, edema, increased skin temperature, reddening and trophic changes characterize complex regional pain syndrome (CRPS). Recently, we have been able to show facilitated neurogenic inflammation on the affected limb. In the current study unaffected limbs were examined after resolution of the CRPS symptoms to assess possible generalized changes predisposing to CRPS. In 12 patients and in 12 healthy volunteers dermal microdialysis in combination with electrical C-fiber stimulation was employed to induce neuropeptide release. Dialysate protein concentration and axon reflex vasodilation were measured. Neither in patients nor in controls did electrical stimulation lead to protein extravasation, while axon reflex vasodilation was significantly enhanced even on the patients" unaffected limbs (P < 0.05). Our results support the hypothesis that facilitated neurogenic inflammation is a predisposing factor for CRPS. The lack of protein extravasation indicates that an initiating trauma is necessary to induce neuropeptide up-regulation in primary afferents.

Useful keywords (using NLM MeSH Indexing)


Complex Regional Pain Syndromes/blood

Complex Regional Pain Syndromes/diagnosis*

Complex Regional Pain Syndromes/immunology

Complex Regional Pain Syndromes/physiopathology*

Disease Susceptibility/blood

Disease Susceptibility/immunology

Disease Susceptibility/physiopathology*

Electric Stimulation/methods*




Middle Aged

Neurogenic Inflammation/blood

Neurogenic Inflammation/diagnosis*

Neurogenic Inflammation/immunology

Neurogenic Inflammation/physiopathology*



Find related publications in this database (Keywords)

complex regional pain syndrome
reflex sympathetic dystrophy
dermal microdialysis
laser Doppler imaging
neurogenic inflammation
genetic predisposition