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Forschungsdatenbank PMU-SQQUID

[GRADE guidelines: 9. Rating up the quality of evidence].
Kien, C; Gartlehner, G; Kaminski-Hartenthaler, A; Meerpohl, JJ; Flamm, M; Langer, G; Perleth, M; Schünemann, HJ;
Z Evid Fortbild Qual Gesundhwes. 2012; 107(3): 249-255.
Originalarbeiten (Zeitschrift)


Flamm Maria


The most common reason for rating up the quality of evidence is a large effect. GRADE suggests considering rating up quality of evidence one level when methodologically rigorous observational studies show at least a two-fold reduction or increase in risk, and rating up two levels for at least a five-fold reduction or increase in risk. Systematic review authors and guideline developers may also consider rating up quality of evidence when a dose-response gradient is present, and when all plausible confounders or biases would decrease an apparent treatment effect, or would create a spurious effect when results suggest no effect. Other considerations include the rapidity of the response, the underlying trajectory of the condition and indirect evidence. Copyright © 2013. Published by Elsevier GmbH.