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Forschungsdatenbank PMU-SQQUID

Flexible dosing of adjunctive zonisamide in the treatment of adult partial-onset seizures: a non-comparative, open-label study (ZEUS).
Dupont, S; Striano, S; Trinka, E; Springub, J; Giallonardo, AT; Smith, P; Ellis, S; Yeates, A; Baker, G;
Acta Neurol Scand. 2010; 121(3):141-148
Originalarbeiten (Zeitschrift)


Trinka Eugen


To assess the efficacy and tolerability of zonisamide in a study allowing flexible dosing in a more diverse and less refractory population than assessed in randomized controlled trials.
This 19-week, non-comparative study of adjunctive zonisamide included 281 adults who had at least four partial-onset seizures within 8 weeks on one or two antiepileptic drugs. Alterations to zonisamide doses were allowed after titration, except during two fixed-dose periods (weeks 10-13 and 16-19).
At the end of the second fixed-dose period (median dose 300 mg/day), the median reduction in monthly seizure frequency was 33.3-41.1%; > or =50% responder rate was 40.9-44.2%; and seizure freedom rate was 15.0-15.9%, depending on the analysis used. The most common adverse events were fatigue (16.7%) and somnolence (15.3%).
Zonisamide demonstrated efficacy in a setting more reflective of clinical practice and was generally well tolerated.

Useful keywords (using NLM MeSH Indexing)




Analysis of Variance

Anticonvulsants/therapeutic use*

Confidence Intervals

Dose-Response Relationship, Drug

Drug Administration Schedule

Drug Therapy, Combination

Epilepsies, Partial/drug therapy*

Epilepsies, Partial/psychology



International Cooperation

Isoxazoles/therapeutic use*


Middle Aged

Quality of Life

Severity of Illness Index

Treatment Outcome

Young Adult

Find related publications in this database (Keywords)

antiepileptic drugs
quality of life