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Forschungsdatenbank PMU-SQQUID

The pathogenic relevance of the prognostic markers CD38 and CD49d in chronic lymphocytic leukemia.
Brachtl, G; Piñón Hofbauer, J; Greil, R; Hartmann, TN;
Ann Hematol. 2014; 93(3): 361-374.
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PMU-Autor/inn/en

Brachtl Gabriele
Greil Richard
Hartmann Tanja
Pinon Hofbauer Josefina

Abstract

The interactions of chronic lymphocytic leukemia cells with the microenvironment in secondary lymphoid tissues and the bone marrow are known to promote CLL cell survival and proliferation. CD38 and CD49d are both independent prognostic risk parameters in CLL with important roles in shaping these interactions. Both are reported to influence CLL cell trafficking between blood and lymphoid organs as well as their survival and proliferation within the lymphoid organs, thereby impacting the pathophysiology of the disease. The expression of CD38 and CD49d is associated in the majority of cases, and they exist as part of macromolecular complexes. Here, we review the current evidence for the individual and associated contributions of these molecules to CLL pathophysiology.


Useful keywords (using NLM MeSH Indexing)

Animals

Antigens, CD38/blood

Antigens, CD38/metabolism*

Cell Movement

Cell Proliferation

Cell Survival

Humans

Integrin alpha4/blood

Integrin alpha4/metabolism*

Integrin alpha4beta1/blood

Integrin alpha4beta1/metabolism

Leukemia, Lymphocytic, Chronic, B-Cell/blood

Leukemia, Lymphocytic, Chronic, B-Cell/diagnosis

Leukemia, Lymphocytic, Chronic, B-Cell/metabolism*

Leukemia, Lymphocytic, Chronic, B-Cell/physiopathology

Membrane Glycoproteins/blood

Membrane Glycoproteins/metabolism*

Models, Biological*

Neoplasm Proteins/blood

Neoplasm Proteins/metabolism*

Prognosis

Tumor Markers, Biological/blood

Tumor Markers, Biological/metabolism*

Tumor Microenvironment


Find related publications in this database (Keywords)

Chronic lymphocytic leukemia
Microenvironment
CD38
CD49d
VLA-4