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Forschungsdatenbank PMU-SQQUID

Cholinergic cortical circuits in Parkinson"s disease and in progressive supranuclear palsy: a transcranial magnetic stimulation study.
Nardone, R; Florio, I; Lochner, P; Tezzon, F
EXP BRAIN RES. 2005; 163(1): 128-131.
Originalarbeiten (Zeitschrift)


Nardone Raffaele


To investigate the involvement of the cortical cholinergic system in patients with Parkinsonxxxs disease (PD) and with progressive supranuclear palsy (PSP), we performed a comparative study of the short latency afferent inhibition (SAI) in ten patients with PD, in eight patients with PSP and in 15 healthy subjects. Six of the PD patients and four of the PSP patients had dementia. SAI was significantly increased in the PD patients, whereas it was not significantly different between PSP patients and the normal controls. Our findings demonstrate that the excitability of the motor cortex is differentially modulated by sensory afferents in PD and PSP and may indicate that the mechanisms of cholinergic dysfunction are different between the two diseases.

Useful keywords (using NLM MeSH Indexing)



Aged, 80 and over

Cholinergic Fibers/physiology*

Electric Stimulation*



Middle Aged

Motor Cortex/physiopathology*

Neural Inhibition

Neurons, Afferent/physiology

Parkinson Disease/physiopathology*

Reaction Time

Receptors, Muscarinic/physiology

Supranuclear Palsy, Progressive/physiopathology*

Transcranial Magnetic Stimulation*

Find related publications in this database (Keywords)

Parkinsonxxxs disease
progressive supranuclear palsy
transcranial magnetic stimulation
afferent inhibition
muscarinic receptors