PMU-Autor/inn/en
Nardone RaffaeleAbstract
To investigate the involvement of the cortical cholinergic system in patients with Parkinsonxxxs disease (PD) and with progressive supranuclear palsy (PSP), we performed a comparative study of the short latency afferent inhibition (SAI) in ten patients with PD, in eight patients with PSP and in 15 healthy subjects. Six of the PD patients and four of the PSP patients had dementia. SAI was significantly increased in the PD patients, whereas it was not significantly different between PSP patients and the normal controls. Our findings demonstrate that the excitability of the motor cortex is differentially modulated by sensory afferents in PD and PSP and may indicate that the mechanisms of cholinergic dysfunction are different between the two diseases.
Useful keywords (using NLM MeSH Indexing)
Acetylcholine/physiology
Aged
Aged, 80 and over
Cholinergic Fibers/physiology*
Electric Stimulation*
Electromyography
Humans
Middle Aged
Motor Cortex/physiopathology*
Neural Inhibition
Neurons, Afferent/physiology
Parkinson Disease/physiopathology*
Reaction Time
Receptors, Muscarinic/physiology
Supranuclear Palsy, Progressive/physiopathology*
Transcranial Magnetic Stimulation*
Find related publications in this database (Keywords)
Parkinsonxxxs disease