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Forschungsdatenbank PMU-SQQUID

Neurogenesis and neuronal regeneration in status epilepticus.
Rotheneichner, P; Marschallinger, J; Couillard-Despres, S; Aigner, L;
Epilepsia. 2013; 54 Suppl 6:40-42
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PMU-Autor/inn/en

Aigner Ludwig
Couillard-Després Sébastien
Marschallinger Julia
Rotheneichner Peter

Abstract

Neurogenesis in the adult central nervous system has been well documented in several mammals including humans. By now, a plethora of data has been generated with the aim of understanding the molecular and cellular events governing neurogenesis. This growing comprehension will provide the basis for modulation of neurogenesis for therapeutic purposes, in particular in neurodegenerative diseases. Herein, we review the current knowledge on neurogenesis, in particular in the frame of epilepsy, since seizures have massive effects on neurogenesis. Conversely, some studies have suggested that aberrant neurogenesis might contribute to the development or manifestation of epilepsy and, moreover, chronic inhibition of neurogenesis in epilepsy might contribute to comorbidities of epilepsy such as cognitive deficits. Therefore, a better understanding of neurogenesis in the context of epilepsy is still required for future therapeutic purposes. Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.


Useful keywords (using NLM MeSH Indexing)

Animals

Humans

Neurogenesis

Neurons/physiology

Regeneration/physiology*

Status Epilepticus/pathology

Status Epilepticus/physiopathology*


Find related publications in this database (Keywords)

Neurogenesis
Status epilepticus
Neuroregeneration