' '
Deutsch | English    

Forschungsdatenbank PMU-SQQUID

IORT with electrons as boost strategy during breast conserving therapy in limited stage breast cancer: long term results of an ISIORT pooled analysis.
Fastner, G; Sedlmayer, F; Merz, F; Deutschmann, H; Reitsamer, R; Menzel, C; Stierle, C; Farmini, A; Fischer, T; Ciabattoni, A; Mirri, A; Hager, E; Reinartz, G; Lemanski, C; Orecchia, R; Valentini, V;
Radiother Oncol. 2013; 108(2):279-286
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Deutschmann Heinz
Fastner Gerd
Fischer Thorsten
Menzel Christian
Reitsamer Roland
Sedlmayer Felix

Abstract

PURPOSE
Linac-based intraoperative radiotherapy with electrons (IOERT) was implemented to prevent local recurrences after breast conserving therapy (BCT) and was delivered as an intraoperative boost to the tumor bed prior to whole breast radiotherapy (WBI). A collaborative analysis has been performed by European ISIORT member institutions for long term evaluation of this strategy.
Until 10/2005, 1109 unselected patients of any risk group have been identified among seven centers using identical methods, sequencing and dosage for intra- and postoperative radiotherapy. A median IOERT dose of 10 Gy was applied (90% reference isodose), preceding WBI with 50-54 Gy (single doses 1.7-2 Gy).
At a median follow up of 72.4 months (0.8-239), only 16 in-breast recurrences were observed, yielding a local tumor control rate of 99.2%. Relapses occurred 12.5-151 months after primary treatment. In multivariate analysis only grade 3 reached significance (p=0.031) to be predictive for local recurrence development. Taking into account patient age, annual in-breast recurrence rates amounted 0.64%, 0.34%, 0.21% and 0.16% in patients <40 years; 40-49 years; 50-59 years and ≥ 60 years, respectively.
In all risk subgroups, a 10 Gy IOERT boost prior to WBI provided outstanding local control rates, comparing favourably to all trials with similar length of follow up.


Useful keywords (using NLM MeSH Indexing)

Adult

Age Factors

Aged

Analysis of Variance

Brachytherapy/methods*

Breast Neoplasms/mortality*

Breast Neoplasms/pathology

Breast Neoplasms/radiotherapy*

Breast Neoplasms/surgery

Cohort Studies

Disease-Free Survival

Electrons/therapeutic use

Female

Follow-Up Studies

Humans

Intraoperative Care/methods*

Mastectomy, Segmental/methods

Middle Aged

Multivariate Analysis

Neoplasm Invasiveness/pathology

Neoplasm Recurrence, Local/mortality

Neoplasm Recurrence, Local/prevention*

control*

Neoplasm Recurrence, Local/therapy

Neoplasm Staging

Postoperative Care/methods

Proportional Hazards Models

Radiotherapy Dosage

Radiotherapy, Adjuvant

Retrospective Studies

Risk Assessment

Survival Analysis

Time Factors

Treatment Outcome

Tumor Burden/radiation effects


Find related publications in this database (Keywords)

Intraoperative radiotherapy
Breast cancer
Boost
Electrons
IOERT