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Forschungsdatenbank PMU-SQQUID

Evaluating an implementation strategy in cardiovascular prevention to improve prescribing of statins in Germany: an intention to treat analysis
Keller, H; Hirsch, O; Kaufmann-Kolle, P; Krones, T; Becker, A; Sonnichsen, AC; Baum, E; Donner-Banzhoff, N
Originalarbeiten (Zeitschrift)


Sönnichsen Andreas


Background: The prescription of statins is an evidence-based treatment to reduce the risk of cardiovascular events in patients with elevated cardiovascular risk or with a cardiovascular disorder (CVD). In spite of this, many of these patients do not receive statins. Methods: We evaluated the impact of a brief educational intervention in cardiovascular prevention in primary care physiciansxxx prescribing behaviour regarding statins beyond their participation in a randomised controlled trial (RCT). For this, prescribing data of all patients > 35 years who were counselled before and after the study period were analysed (each n > 75000). Outcome measure was prescription of Hydroxymethylglutaryl-CoA Reductase Inhibitors (statins) corresponding to patientsxxx overall risk for CVD. Appropriateness of prescribing was examined according to different risk groups based on the Anatomical Therapeutic Chemical Classification System (ATC codes). Results: There was no consistent association between group allocation and statin prescription controlling for risk status in each risk group before and after study participation. However, we found a change to more significant drug configurations predicting the prescription of statins in the intervention group, which can be regarded as a small intervention effect. Conclusion: Our results suggest that an active implementation of a brief evidence-based educational intervention does not lead to prescription modifications in everyday practice. Physicianxxxs prescribing behaviour is affected by an established health care system, which is not easy to change.

Find related publications in this database (Keywords)

Evaluation studies
Intention to treat analysis
Cardiovascular diseases
Drug prescriptions
Hydroxymethylglutaryl-CoA Reductase Inhibitors