It has been established that lesions in the temporal lobe of the dominant hemisphere lead to specific deficits in memory performance. Furthermore, there is a relationship between memory performance and alpha frequency. We compared the individually determined dominant alpha frequency of patients with a lesion in the temporal lobe of the dominant hemisphere with those with a lesion in the subdominant hemisphere. Purpose: To investigate the memory performance and alpha peak frequency in patients with temporal lobe epilepsy and to correlate this with side of the lesion. Methods: Nine patients (mean age 29.1, SD 12.6) with unilateral temporal robe epilepsy (TLE) were examined. The Wechsler Memory Scale (WMS) was used for all patients to test the memory performance. The EEG-alpha peak was determined individually for each patient using a power-spectrum calculated within a 15-minute artifact-free EEG-epoch during a resting condition with eyes closed. Results: The results indicate that patients with a lesion in the dominant hemisphere shows significantly poorer memory performance as compared to patients with a lesion in the subdominant hemisphere. in addition, the group of patients with poorer memory performance show a tendency towards a lower alpha peak. Furthermore, statistical analysis gives evidence of a lower alpha peak in the EEC of patients with a lesion in the dominant hemisphere. Conclusion: We conclude that the localization of the lesion is a predominant factor for memory performance and alpha frequency in patients with unilateral temporal to be epilepsy.
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