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Forschungsdatenbank PMU-SQQUID

uCyt+/ImmunoCyt in the detection of recurrent urothelial carcinoma: an update on 1991 analyses.
Mian, C; Maier, K; Comploj, E; Lodde, M; Berner, L; Lusuardi, L; Palermo, S; Vittadello, F; Pycha, A;
Cancer. 2006; 108(1): 60-65.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Lusuardi Lukas

Abstract

BACKGROUND. The authors provide an update on the clinical value and role of the uCyt+/ImmunoCyt((TM)) test as a noninvasive tool for the detection of recurrent urothelial carcinoma. METHODS. Between January 2002 and October 2004, 942 patients (mean age, 72.6 yrs; range, 32-87 yrs) were enrolled in this prospective study. These patients mostly had been followed for superficial urothelial carcinoma (UC) confined to the mucosa and lamina propria (pathologic tumor [pT] classification pTa, pT1, and pTis [carcinoma in situ]) for a mean of 15.62 months (range, 4-28 mos). Voided urinary cytology and the uCyt+/ImmunoCyt test for all patients were performed on liquid-based cytology slides. Patients underwent subsequent cystoscopy when cytology or uCyt+/ImmunoCyt results were positive and when they underwent biopsy evaluation of any suspicious lesion. Altogether, 1991 uCyt+/ImmunoCyt analyses were performed. RESULTS. Two hundred ninety-eight patients who had adequate samples available were diagnosed with histologically proven UC. The sensitivity of cytology increased from 8.3% for Grade 1 tumors to 75.3% for Grade 3 tumors; whereas, with the uCyt+/ImmunoCyt, the sensitivity was 79.3% for Grade 1 tumors, 84.1% for Grade 2 tumors, and 92.1% for Grade 3 tumors. For cytology and uCyt+/ImmunoCyt combined, the sensitivity was 79.3% for Grade 1 tumors, 90.9% for Grade 2 tumors, and 98.9% for Grade 3 tumors. CONCLUSIONS. The current data confirmed the clinical usefulness of the uCyt+/ImmunoCyt test in the follow-up of patients with recurrent UC. Used as a noninvasive tool, cytology escorted by uCyt+/ImmunoCyt may reduce the morbidity and cost of follow-up for patients who have a low risk of recurrence while avoiding superfluous cystoscopic examinations. However, additional studies will be necessary to establish and compare the morbidity and cost of each method.


Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Aged, 80 and over

Antibodies, Monoclonal/diagnostic use*

Antigens, Neoplasm/immunology

Antigens, Neoplasm/metabolism

Female

Humans

Immunohistochemistry

Male

Middle Aged

Neoplasm Recurrence, Local/prevention*

control*

Sensitivity and Specificity

Urinary Bladder Neoplasms/diagnosis*


Find related publications in this database (Keywords)

recurrent urothelial carcinoma
immunofluorescence
uCyt plus /ImmunoCyt (TM) surveillance