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Forschungsdatenbank PMU-SQQUID

Soluble ICAM-1 in breast cancer: clinical significance and biological implications.
Köstler, WJ; Tomek, S; Brodowicz, T; Budinsky, AC; Flamm, M; Hejna, M; Krainer, M; Wiltschke, C; Zielinski, CC;
Cancer Immunol Immunother. 2001; 50(9):483-490
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Flamm Maria

Abstract

In previous experiments, we demonstrated a decreased expression of intercellular adhesion molecule I (ICAM-1) on both tumour cells and antigen-presenting cells derived from patients with breast cancer, resulting in an abrogation of antigen presentation and tumour cell lysis. Recently, increased levels of a soluble isoform of ICAM-1 (sICAM-1) have been detected in the sera of breast cancer patients. The present investigation was performed in order to investigate the biological relevance of serum concentrations and the effects of sICAM-1 in patients with breast cancer.


Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Antigen Presentation

Breast Neoplasms/blood*

CD4-Positive T-Lymphocytes

Chromium/metabolism

Disease Progression

Enzyme-Linked Immunosorbent Assay

Female

Flow Cytometry

Humans

Intercellular Adhesion Molecule-1/blood*

Middle Aged

Neoplasm Staging

Receptor, ErbB-2/metabolism

Tumor Cells, Cultured


Find related publications in this database (Keywords)

sICAM-1
breast cancer
ADCC
antigen presentation