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Forschungsdatenbank PMU-SQQUID

Visual cortex hyperexcitability in idiopathic generalized epilepsies with photosensitivity: a TMS pilot study.
Brigo, F; Bongiovanni, LG; Nardone, R; Trinka, E; Tezzon, F; Fiaschi, A; Manganotti, P
Epilepsy Behav. 2013; 27(2):301-306
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Nardone Raffaele
Trinka Eugen

Abstract

BACKGROUND
The current understanding of the mechanisms underlying photosensitivity is still limited, although most studies point to a hyperexcitability of the visual cortex.
Using transcranial magnetic stimulation, we determined the resting motor threshold (rMT) and the phosphene threshold (PT) in 33 patients with IGEs (8 with photosensitivity) compared with 12 healthy controls.
Eleven controls (92%) reported phosphenes compared with fifteen (46%) patients with idiopathic generalized epilepsy (p=0.015). Phosphenes were reported more frequently among patients with epilepsy with photosensitivity (87.5%) than in patients with active epilepsy without photosensitivity (30.8%) (p=0.038) and patients with epilepsy in remission without photosensitivity (33.3%) (p=0.054); no differences were found between patients with epilepsy with photosensitivity and controls (p=0.648). Resting motor threshold and phosphene threshold were significantly higher among patients with epilepsy (active epilepsy or epilepsy in remission without photosensitivity) compared to healthy controls (p<0.01). Conversely, patients with active epilepsy and photosensitivity had significantly lower values than controls (p=0.03).
The marked decrease in PT and the high phosphene prevalence in patients with IGE with photosensitivity indicate a regional hyperexcitability of the primary visual cortex. Results of this study also suggest that the PT may serve as a biomarker for excitability in patients with IGE and photosensitivity.


Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Analysis of Variance

Epilepsy, Generalized/complications

Epilepsy, Generalized/pathology*

Female

Humans

Linear Models

Male

Middle Aged

Phosphenes/physiology*

Photosensitivity Disorders/complications

Photosensitivity Disorders/pathology*

Pilot Projects

Sensory Thresholds

Transcranial Magnetic Stimulation*

Visual Cortex/physiopathology*

Young Adult


Find related publications in this database (Keywords)

Idiopathic generalized epilepsy
Motor threshold
Phosphene threshold
Photosensitivity
Transcranial magnetic stimulation