Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

OBJECTIVE
Since the clinical observations published by Janz in 1957, the presence of personality irregularities in patients with juvenile myoclonic epilepsy (JME) has been described repeatedly, but never quantified using standardized assessments. The aim of the present study was to investigate whether juveniles with a short history of JME exhibit psychopathological symptoms and/or personality irregularities.
We used standardized assessments, the Youth Self Report (YSR) and the Weinberger Adjustment Inventory (WAI).
Of 38 patients who fulfilled the study entry criteria, 25 agreed to participate and completed all surveys. On the YSR, our sample exhibited twice the amount of psychiatric symptoms than age-matched norms. Furthermore, psychopathological symptoms increased with duration of JME. According to WAI results, JME significantly affected self-restraint: patients with longer disease duration showed less self-control.
Adolescents with JME present not only with neurological abnormalities but also with significant psychopathology and personality irregularities. Our data suggest that psychological and behavioral changes are dynamic processes dependent on the progression of the disease.

Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Anticonvulsants/adverse effects

Anticonvulsants/therapeutic use

Child

Ethosuximide/therapeutic use

Female

Fructose/analogs*

derivatives

Fructose/therapeutic use

Humans

Male

Mental Disorders/etiology*

Mental Disorders/psychology*

Myoclonic Epilepsy, Juvenile/drug therapy

Myoclonic Epilepsy, Juvenile/psychology*

Personality*

Personality Tests

Piracetam/analogs*

derivatives

Piracetam/therapeutic use

Psychiatric Status Rating Scales

Questionnaires

Triazines/therapeutic use

Valproic Acid/therapeutic use

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