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Forschungsdatenbank PMU-SQQUID

Specificities of platelet autoantibodies and platelet activation in lupus anticoagulant patients: a relation to their history of thromboembolic disease.
Schallmoser, K; Rosin, C; Vormittag, R; Brunner, M; Dunkler, D; Pabinger, I; Panzer, S;
Lupus. 2006; 15(8):507-514
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Schallmoser Katharina

Abstract


Lupus anticoagulants (LA) prolong in vitro phospholipid-dependent coagulation tests, but are associated with thromboembolic disease (TE). However, a subgroup of individuals with LA has no TE, and it is therefore desirable to distinguish those at risk for TE from those without. Whether platelets have a primary role in the development of TE is not clear yet. We determined platelet autoantibodies to identify a specific platelet target which is associated with platelet activation in 97 patients with a long history of detectable LA, 65 patients with TE (LA/TE+), and 32 individuals without TE (LA/TE-). Thrombocytopenia was more common in the LA/TE- than in the LA/TE+ group (P < 0.05). Both groups had platelet antibodies, but the frequency of antibodies was lower in LA/TE+ than LA/TE- patients (P < 0.01), who had higher antibody titres against glycoprotein IIb/IIIa and glycoprotein Ib/IX (P < 0.05). Also, their platelets were more activated, as determined by PAC-1 binding (P < 0.01). These differences were also noted if patients with arterial thrombosis were evaluated separately. These findings in LA/TE- individuals were similar to those in patients with chronic autoimmune thrombocytopenia. However, there was no autoantibody target identifiable to distinguish between LA/TE- from LA-TE+ individuals. We therefore conclude that the presence of platelet antibodies, even if associated with platelet activation, is not sufficient to dispose LA patients to thromboembolic disease.


Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Aged

Antiphospholipid Syndrome/immunology

Autoantibodies/immunology*

Blood Coagulation Tests

Blood Platelets/immunology*

Child

Female

Humans

Lupus Coagulation Inhibitor/immunology*

Middle Aged

Platelet Activation*

Platelet Membrane Glycoproteins/immunology

Random Allocation

Thrombocytopenia/immunology

Thromboembolism/immunology*

beta 2-Glycoprotein I/immunology


Find related publications in this database (Keywords)

lupus anticoagulant
platelet activation
platelet autoantibodies
thromboembolic disease