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Forschungsdatenbank PMU-SQQUID

The Fc gammaRIIa polymorphism R/H131, autoantibodies against the platelet receptors GPIb alpha and Fc gammaRIIa and a risk for thromboembolism in lupus anticoagulant patients.
Schallmoser, K; Rosin, C; Knittelfelder, R; Sailer, T; Ulrich, S; Zoghlami, C; Lehr, S; Pabinger, I; Panzer, S;
Thromb Haemost. 2005; 93(3):544-548
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Schallmoser Katharina

Abstract


There is a clear propensity of individuals with lupus anticoagulant (LA) for thromboembolic disease (TE). Yet, it is not clear how individuals at risk for TE can be differentiated from those who are not. The Fc gammaRIIa receptor is the only Fc receptor expressed by platelets. As platelets can be activated via this receptor, we have compared gene frequencies of the Fc gammaRIIa polymorphism R/H131 in 46 and 27 patients with (LA/TE+) and without TE (LA/TE-), respectively, in an exploratory study. Furthermore, we investigated the presence of autoantibodies against Fc gammaRIIa and/or GPIb alpha, which is in close proximity to the Fc gammaRIIa and interacts with it functionally, and a possible linkage of antibody formation to HLA class II alleles. The Fc gammaRIIa-R/R131 genotype was significantly less frequent in patients with LA compared to controls (p<0.025). These findings were due to an increased frequency of heterozygous patients in the LA/TE+ cohort (odds ratio 6.76, 95% confidence interval 1.55-62.03, p<0.008). For the first time, heterozygosity, rather than homozygosity, can be linked to disease, which may be explained by the dual function of the Fc gammaRIIa, namely binding of antibodies to platelets and thereby their activation, and, on the other hand, clearance of antibody coated platelets by the phagocyte system. There was no correlation between the presence of anti-Fc gammaRIIa or anti-GPIb alpha autoantibodies and the Fc gammaRIIa-R/H131 polymorphism, nor the incidence of TE, nor HLA class II alleles.


Useful keywords (using NLM MeSH Indexing)

Adolescent

Adult

Aged

Aged, 80 and over

Autoantibodies/blood*

Case-Control Studies

Child

Gene Frequency

Heterozygote

Homozygote

Humans

Lupus Coagulation Inhibitor*

Membrane Glycoproteins

Membrane Proteins/immunology*

Middle Aged

Mutation, Missense

Odds Ratio

Polymorphism, Genetic*

Receptors, Fc/genetics*

Receptors, Fc/immunology*

Receptors, Fc/physiology

Receptors, IgG/genetics

Receptors, IgG/immunology

Risk

Thromboembolism/etiology*

Thromboembolism/genetics

Thromboembolism/immunology


Find related publications in this database (Keywords)

lupus anticoagulant
Fc gamma RIIa receptor
GPIb alpha
thromboembolic disease