PMU-Autor/inn/en
Kraus JörgAbstract
The intercellular adhesion molecule-1 (ICAM-1) is a member of the Ig supergene family. ICAM-1 is expressed on various cells like peripheral blood lymphocytes, endothelial cells or thymic cells and the cell surface form is supposed to be shed into a soluble form. The expression of ICAM-1 is induced by cytokines like Interleukin-1, TNF alpha or interferon gamma. The aim of the study was to investigate whether changes of cell surface and soluble ICAM-1 in the cerebrospinal fluid (CSF) and blood are indicative for disease activity in patients with multiple sclerosis (MS).
Useful keywords (using NLM MeSH Indexing)
Adolescent
Adult
Biological Markers/analysis
Female
Humans
Intercellular Adhesion Molecule-1/blood
Intercellular Adhesion Molecule-1/cerebrospinal fluid
Intercellular Adhesion Molecule-1/metabolism*
Male
Middle Aged
Multiple Sclerosis/classification
Multiple Sclerosis/immunology*
Recurrence
Time Factors
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cerebrospinal fluid