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Forschungsdatenbank PMU-SQQUID

Soluble and cell surface ICAM-1 as markers for disease activity in multiple sclerosis.
Kraus, J; Oschmann, P; Engelhardt, B; Schiel, C; Hornig, C; Bauer, R; Kern, A; Traupe, H; Dorndorf, W;
Acta Neurol Scand. 1998; 98(2): 102-109.
Originalarbeiten (Zeitschrift)


Kraus Jörg


The intercellular adhesion molecule-1 (ICAM-1) is a member of the Ig supergene family. ICAM-1 is expressed on various cells like peripheral blood lymphocytes, endothelial cells or thymic cells and the cell surface form is supposed to be shed into a soluble form. The expression of ICAM-1 is induced by cytokines like Interleukin-1, TNF alpha or interferon gamma. The aim of the study was to investigate whether changes of cell surface and soluble ICAM-1 in the cerebrospinal fluid (CSF) and blood are indicative for disease activity in patients with multiple sclerosis (MS).

Useful keywords (using NLM MeSH Indexing)



Biological Markers/analysis



Intercellular Adhesion Molecule-1/blood

Intercellular Adhesion Molecule-1/cerebrospinal fluid

Intercellular Adhesion Molecule-1/metabolism*


Middle Aged

Multiple Sclerosis/classification

Multiple Sclerosis/immunology*


Time Factors

Find related publications in this database (Keywords)

cerebrospinal fluid
multiple sclerosis
disease activity
central nervous system