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Forschungsdatenbank PMU-SQQUID

Persistent detrusor overactivity after transurethral resection of the prostate is associated with reduced perfusion of the urinary bladder
Mitterberger, M; Pallwein, L; Gradl, J; Frauscher, F; Neuwirt, H; Leunhartsberger, N; Strasser, H; Bartsch, G; Pinggera, GM
BJU INT. 2007; 99(4): 830-834.
Originalarbeiten (Zeitschrift)


Mitterberger Michael


OBJECTIVES To elucidate, in patients with benign prostatic hyperplasia (BPH), how often detrusor overactivity (DOA) is persistent after transurethral resection of the prostate (TURP) and if perfusion of the lower urinary tract influences postoperative outcomes. PATIENTS AND METHODS Fifty men with urodynamically confirmed DOA and bladder outlet obstruction due to BPH had a TURP. Before and 1 year after TURP the International Prostate Symptom Score (IPSS), quality of life (QoL) score, prostate-specific antigen (PSA) level and total prostatic volume (TPV) were evaluated. Also, the lower urinary tract was evaluated using pressure-flow studies and transrectal colour Doppler ultrasonography to assess the vascular resistive index (RI) as a variable of the perfusion of the lower urinary tract. RESULTS After TURP the IPSS, QoL score, PSA level and TPV decreased. Cystometric measurements showed that in 15 (30%) patients DOA was persistent after TURP. The mean (SD) maximum urinary flow rate increased from 9.20 (4.03) to 15.98 (4.62) mL/s and postvoiding residual urine volumes decreased from 109.38 (73.71) to 29.24 (45.00) mL. When men with persistent DOA (15 patients; group 1) were compared with those with no DOA after TURP (35; group 2) there was a statistically significantly higher RI of the bladder vessels in group 1, at 0.86 (0.068) than in group 2, at 0.68 (0.055) (P < 0.001). CONCLUSIONS Persistent DOA in men after TURP seems to be associated with increased vascular resistance of the bladder vessels with subsequent reduced perfusion and hypoxia.

Useful keywords (using NLM MeSH Indexing)




Prostate-Specific Antigen/blood

Prostatic Hyperplasia/complications

Prostatic Hyperplasia/physiopathology

Prostatic Hyperplasia/surgery*

Quality of Life

Transurethral Resection of Prostate*

Treatment Outcome

Urinary Bladder, Overactive/etiology*

Urinary Bladder, Overactive/physiopathology

Urinary Tract/blood supply*

Urinary Tract/ultrasonography


Find related publications in this database (Keywords)

detrusor overactivity
benign prostatic hyperplasia
benign prostatic enlargement