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Forschungsdatenbank PMU-SQQUID

A prospective randomized trial comparing contrast-enhanced targeted versus systematic ultrasound guided biopsies: impact on prostate cancer detection.
Mitterberger, M; Horninger, W; Pelzer, A; Strasser, H; Bartsch, G; Moser, P; Halpern, EJ; Gradl, J; Aigner, F; Pallwein, L; Frauscher, F;
Prostate. 2007; 67(14):1537-1542
Originalarbeiten (Zeitschrift)


Mitterberger Michael


BACKGROUND: We performed a prospective randomized trial comparing 5 contrast-enhanced color Doppler (CECD) ultrasound (US) targeted biopsy cores to 10 gray-scale US guided systematic biopsy (SB) cores to determine the impact on the cancer detection rate. METHODS:. We prospectively randomized 100 prostate specific antigen (PSA) screening volunteers with an elevated PSA (>= 1.25 ng/ml and free-to-total PSA < 18%) to undergo contrast-enhanced targeted or SB. Contrast-enhanced targeted biopsies with a limited number of five cores were performed into hypervascular areas of the peripheral zone (PZ) during administration of the US contrast agent SonoVue (R) (Bracco, Italy). A subjective grading of the vascularity from 0 to 3 was used: grade 0, no color signal; 1, low density; 2, medium density; and 3, high density of color signals. Ten SBs were obtained in a standard spatial distribution. Cancer detection rates were compared in the groups. RESULTS: Cancer was detected in 16/50 subjects (32%) by targeted biopsy, and in 13/50 patients (26%) with SB. The cancer detection rate was significantly better for the targeted approach (P < 0.04, McNemar). The detection rate for targeted biopsy cores (15.6% or 39/250 cores) was significantly better than for SB cores (6.8% or 34/500 cores, P < 0.001, McNemar). CONCLUSIONS:. CECD targeted biopsy detected more cancers than SB with a reduced number of biopsy cores.

Useful keywords (using NLM MeSH Indexing)









Middle Aged

Predictive Value of Tests

Prospective Studies

Prostate-Specific Antigen/blood

Prostatic Neoplasms/blood

Prostatic Neoplasms/surgery

Prostatic Neoplasms/ultrasonography*

Ultrasonography, Doppler, Color*

Find related publications in this database (Keywords)

prostate cancer
contrast-enhanced ultrasound
prostate biopsy