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Forschungsdatenbank PMU-SQQUID

Polypharmacy and inappropriate prescribing in elderly internal-medicine patients in Austria
Schuler, J; Duckelmann, C; Beindl, W; Prinz, E; Michalski, T; Pichler, M
WIEN KLIN WOCHENSCHR. 2008; 120(23-24): 733-741.
Originalarbeiten (Zeitschrift)


Schuler Jochen


Objective: The aim of the study was to assess the prevalence of polypharmacy and inappropriate drug use in elderly internal-medicine patients in one Austrian center and to define the impact of these and other identified predictors on the occurrence of adverse drug eve tits. Methods: All patients >= 75 years admitted to selected internal wards of a university hospital were included in a monocentric prospective cohort study over a period of three months. The pre-admission medication of the patients was analyzed with respect to appropriateness by a multidisciplinary teals consisting of pharmacists and physicians trained in internal medicine. The medication was evaluated for the occurrence of adverse drug events. Results: A total of 543 patients were analyzed (median age 82 years; 60.2% female). The mean number of drugs taken was 7.5 +/- 3.8, with women taking significantly more drugs than men (7.8 vs. 6.8, P = 0.013). Overall, 58.4% of the patients fulfilled the given criteria for polypharmacy (>6 drugs). The following factors were associated with polypharmacy: female sex, need for nursing care, high number of discharge diagnoses and high Charlson comorbidity score. Unnecessary drugs were found prescribed in 36.3% of all patients, drugs to avoid (Beers criteria) in 30.1%, duplication in 7.6%, wrong dosage in 23.4% and possible drug-drug interactions in 65.8%. Adverse drug events were identified in 17.8% of the patients (97/543), among whom the adverse drug event was the reason for hospital admission in 56.7% of the cases and a drug-drug interaction wets involved in 18.7%. Risk factors for adverse drug events were female sex, polymorbidity, renal dysfunction and inappropriate prescribing. Conclusion: Polypharmacy, inappropriate prescribing and adverse drug events were highly prevalent in a cohort of elderly internal-medicine patients in Austria. To improve drug safety in this high-risk population, appropriate prescribing might be more important than simply reducing the number of prescribed drugs.

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inappropriate prescribing
adverse drug events