Malfunction of the SLC26A4 protein leads to prelingual deafness often associated with mild thyroid dysfunction and goiter. It is assumed that SLC26A4 acts as a chloride/anion exchanger responsible for the iodide organification in the thyroid gland, and conditioning of the endolymphatic fluid in the inner ear.
Useful keywords (using NLM MeSH Indexing)
Biological Transport/drug effects
Hearing Loss, Sensorineural/genetics*
Membrane Transport Proteins/drug effects
Membrane Transport Proteins/genetics*
Membrane Transport Proteins/metabolism*
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