PMU-Autor/inn/en
Paulmichl MarkusAbstract
ICln is a ubiquitously expressed eukaryotic protein. Expression of the protein in Xenopus laevis oocytes, the knocking-down of the protein in fibroblasts, or the reconstitution of the protein in lipid bilayer led to the assumption that this protein is an ionic channel or a significant part thereof. However, other possible roles for ICln in potential regulatory mechanisms have been postulated, as diverse as regulator of cell morphology by interacting with the Skb1 protein and/or interaction with core spliceosomal proteins. Here we show that ICln is able to interact with SnRNP core proteins SmD1, SmD2, SmD3, SmX5 and SmB/B".
Useful keywords (using NLM MeSH Indexing)
Amino Acid Sequence
Animals
Base Sequence
Gene Library
Genes, Reporter/genetics
Humans
Ion Channels*
Molecular Sequence Data
Protein Binding
Proteins/genetics*
Proteins/metabolism*
Recombinant Fusion Proteins/genetics
Recombinant Fusion Proteins/metabolism*
Ribonucleoproteins, Small Nuclear/chemistry
Ribonucleoproteins, Small Nuclear/genetics
Ribonucleoproteins, Small Nuclear/metabolism*
Saccharomyces cerevisiae/genetics
Two-Hybrid System Techniques*
Find related publications in this database (Keywords)
ICln