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Forschungsdatenbank PMU-SQQUID

Determination of protein-protein interactions of ICIn by the yeast two-hybrid system.
Schmarda, A; Fresser, F; Gschwentner, M; Fürst, J; Ritter, M; Lang, F; Baier, G; Paulmichl, M;
Cell Physiol Biochem. 2001; 11(1): 55-60.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Paulmichl Markus
Ritter Markus

Abstract

ICln is a ubiquitously expressed eukaryotic protein. Expression of the protein in Xenopus laevis oocytes, the knocking-down of the protein in fibroblasts, or the reconstitution of the protein in lipid bilayer led to the assumption that this protein is an ionic channel or a significant part thereof. However, other possible roles for ICln in potential regulatory mechanisms have been postulated, as diverse as regulator of cell morphology by interacting with the Skb1 protein and/or interaction with core spliceosomal proteins. Here we show that ICln is able to interact with SnRNP core proteins SmD1, SmD2, SmD3, SmX5 and SmB/B".


Useful keywords (using NLM MeSH Indexing)

Amino Acid Sequence

Animals

Base Sequence

Gene Library

Genes, Reporter/genetics

Humans

Ion Channels*

Molecular Sequence Data

Protein Binding

Proteins/genetics*

Proteins/metabolism*

Recombinant Fusion Proteins/genetics

Recombinant Fusion Proteins/metabolism*

Ribonucleoproteins, Small Nuclear/chemistry

Ribonucleoproteins, Small Nuclear/genetics

Ribonucleoproteins, Small Nuclear/metabolism*

Saccharomyces cerevisiae/genetics

Two-Hybrid System Techniques*


Find related publications in this database (Keywords)

ICln
IClswell
SmD1
SmD2
SmD3
SmX5
SmB/B xxx
Skb1