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Forschungsdatenbank PMU-SQQUID

PTEN, pAKT, and pmTOR expression and subcellular distribution in primary renal cell carcinomas and their metastases.
Hager, M; Haufe, H; Lusuardi, L; Schmeller, N; Kolbitsch, C;
Cancer Invest. 2011; 29(7):427-438
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Hager Martina
Haufe Heike
Lusuardi Lukas

Abstract

The present study evaluated pAKT, pmTOR, and PTEN expression in a tissue microarray of primary renal cell carcinomas (PRCCs), their metastases, and normal renal parenchyma (NRP) (N = 45) by means of immunohistochemistry. Metastases in most subcellular compartments showed comparable and stronger expression for pAKT, pmTOR, and PTEN than PRCC and NRP, which was even more pronounced in patients with high-risk Memorial Sloan-Kettering Cancer Center (MSKCC) score. Furthermore, most subcellular compartments showed no differences between lymphogenous, haematogenous, synchronous, and metachronous metastases, which is interesting with regard to sensitivity to mTOR inhibitor therapy in metastasized RCCs with alterations in the PI3K/AKT pathway.


Useful keywords (using NLM MeSH Indexing)

Aged

Carcinoma, Renal Cell/chemistry

Carcinoma, Renal Cell/drug therapy

Carcinoma, Renal Cell/pathology*

Cytoplasm/chemistry

Female

Humans

Kidney Neoplasms/chemistry

Kidney Neoplasms/drug therapy

Kidney Neoplasms/pathology*

Male

Middle Aged

Neoplasm Metastasis

PTEN Phosphohydrolase/analysis*

PTEN Phosphohydrolase/physiology

Phosphorylation

Proto-Oncogene Proteins c-akt/metabolism*

TOR Serine-Threonine Kinases/antagonists*

inhibitors

TOR Serine-Threonine Kinases/metabolism*


Find related publications in this database (Keywords)

Primary renal cell carcinoma
Metastases
PTEN
pAKT
pmTOR