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Forschungsdatenbank PMU-SQQUID

Isolated leptomeningeal infiltration of a primary CNS B-cell lymphoma diagnosed by flow cytometry and confirmed by necropsy.
Broussalis, E; Hutterer, M; Oppermann, K; Wipfler, P; Pilz, G; Harrer, A; Haschke-Becher, E; Golaszewski, S; Schönauer, U; Weis, S; Killer-Oberpfalzer, M; Mc Coy, M; Trinka, E; Kraus, J;
Acta Neurol Scand. 2012; 126(3):e11-e16


Golaszewski Stefan
Harrer Andrea
Haschke-Becher Elisabeth
Killer-Oberpfalzer Monika
Kraus Jörg
McCoy Mark R.
Müller-Thies-Broussalis Erasmia
Oppermann Katrin
Pilz Georg
Trinka Eugen
Wipfler Peter


The diagnosis of the isolated leptomeningeal involvement of a primary central nervous system B-cell lymphoma without parenchyma lesions may be difficult. Patients with leptomeningeal meningeosis lymphomatosa can present with various neurologic deficits.
To demonstrate the impact of cerebrospinal fluid (CSF) flow cytometry in the diagnosis of an isolated leptomeningeal manifestation of B-cell lymphoma by presenting an interesting case report.
Flow cytometric analysis of B-cell monoclonality of the CSF was performed as complementary diagnostic procedure in addition to CSF cytology. Final diagnosis was confirmed by necropsy.
We suspected isolated leptomeningeal manifestation of B-cell lymphoma with palsy of the VI and VII cranial nerves in a 79-year-old male, because of mononuclear pleocytosis in CSF. Interestingly, the decisive diagnostic hint was given by implementation of flow cytometry of the CSF. Diagnosis was confirmed by postmortem autopsy.
Our case shows that flow cytometry of the CSF in addition to conventional CSF cytology has the potential to accelerate diagnosis of lymphomeningeal infiltration of B-cell lymphoma.

Useful keywords (using NLM MeSH Indexing)


Central Nervous System Neoplasms/cerebrospinal fluid

Central Nervous System Neoplasms/pathology*

Cytological Techniques

Flow Cytometry*


Lymphoma, Non-Hodgkin/cerebrospinal fluid

Lymphoma, Non-Hodgkin/pathology*


Meningeal Neoplasms/cerebrospinal fluid

Meningeal Neoplasms/diagnosis*

Meningeal Neoplasms/secondary*


Find related publications in this database (Keywords)

leptomeningeal infiltration
B-cell lymphoma
flow cytometry
cranial nerve palsy
cerebrospinal fluid