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Forschungsdatenbank PMU-SQQUID

Comparison of Epidemiological Data of Complex Regional Pain Syndrome (CRPS) Patients in Relation to Disease Severity-A Retrospective Single-Center Study.
Diepold, J; Deininger, C; Von Amelunxen, BC; Deluca, A; Siegert, P; Freude, T; Wichlas, F;
Int J Environ Res Public Health. 2023; 20(2):
Originalarbeiten (Zeitschrift)


Deininger Christian
Diepold Julian
Freude Thomas
Wichlas Florian


A retrospective data analysis of 159 complex regional pain syndrome (CRPS) patients (n = 116 women, 73.0%, mean age 60.9 ± 14.4 years; n = 43 men, 27.0%, mean age 52.3 ± 16.7 years) was performed from 2009 to 2020. The right side was affected in 74 patients (46.5%), the left in 84 patients (52.8%), and 1 patient (0.7%) developed a bilateral CRPS. Data were analyzed for the frequency and distribution of symptoms. The number of reduction maneuvers and the number of Budapest criteria were compared in relation to the severity of CRPS. Hand and wrist (n = 107, 67.3%), followed by foot and ankle (n = 36, 22.6%) and other locations (n = 16, 10.1%) were mainly affected by CRPS. The main causes included direct trauma (n = 120, 75.5%), surgery without previous trauma (n = 25, 15.7%), other causes (n = 9, 5.7%), and spontaneous development (n = 3, 1.9%); there was also missing documentation (n = 2, 1.3%). The most common symptoms were difference in temperature (n = 156, 98.1%), limitation of movement (n = 149, 93.7%), and swelling (n = 146, 91.8%). There was no correlation between the number of reduction maneuvers and the number of Budapest criteria. In summary, patients with the following constellation are at increased risk of CRPS: a female, over 60 years old, who has fallen and has sustained a fracture in the hand or wrist with persistent pain and has been immobilized with a cast for approx. 4 weeks.

Useful keywords (using NLM MeSH Indexing)




Middle Aged



Retrospective Studies

Radius Fractures*/complications

Radius Fractures*/diagnosis

Complex Regional Pain Syndromes*/epidemiology

Complex Regional Pain Syndromes*/etiology

Complex Regional Pain Syndromes*/diagnosis


Patient Acuity