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Forschungsdatenbank PMU-SQQUID

The effectiveness of anticonvulsants in psychiatric disorders.
Grunze, HC;
Dialogues Clin Neurosci. 2008; 10(1):77-89


Grunze Heinz


Anticonvulsant drugs are widely used in psychiatric indications. These include mainly alcohol and benzodiazepine withdrawal syndromes, panic and anxiety disorders, dementia, schizophrenia, affective disorders, bipolar affective disorders in particular, and, to some extent, personality disorders. A further area in which neurology and psychiatry overlap is pain conditions, in which some anticonvulsants, and also typical psychiatric medications such as antidepressants, are helpful. From the beginning of their psychiatric use, anticonvulsants have also been used to ameliorate specific symptoms of psychiatric disorders independently of their causality and underlying illness, eg, aggression, and, more recently, cognitive impairment, as seen in affective disorders and schizophrenia. With new anticonvulsants currently under development, it is likely that their use in psychiatry will further increase, and that psychiatrists need to learn about their differential efficacy and safety profiles to the same extent as do neurologists.

Useful keywords (using NLM MeSH Indexing)


Anticonvulsants/therapeutic use*

Anxiety Disorders/drug therapy

Anxiety Disorders/metabolism

Anxiety Disorders/physiopathology

Bipolar Disorder/drug therapy

Bipolar Disorder/metabolism

Bipolar Disorder/physiopathology

Brain/drug effects*




Mood Disorders/drug therapy

Mood Disorders/metabolism

Mood Disorders/physiopathology

Neurocognitive Disorders/drug therapy*

Neurocognitive Disorders/metabolism

Neurocognitive Disorders/physiopathology

Personality Disorders/drug therapy

Personality Disorders/metabolism

Personality Disorders/physiopathology

Schizophrenia/drug therapy



Substance-Related Disorders/drug therapy

Substance-Related Disorders/metabolism

Substance-Related Disorders/physiopathology

Treatment Outcome