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Forschungsdatenbank PMU-SQQUID

Hypoxia Inhibits Colonic Ion Transport via Activation of AMP Kinase
Collins, D; Kopic, S; Bachlechner, J; Ritter, M; Winter, DC; Geibel, JP
ANN SURG. 2011; 254(6): 957-963.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Ritter Markus

Abstract

Mucosal hypoxia is a common endpoint for many pathological processes including ischemic colitis, colonic obstruction and anastomotic failure. Previous studies suggest that hypoxia modulates colonic mucosal function through inhibition of chloride secretion. However, the molecular mechanisms underlying this observation are poorly understood. AMP-activated protein kinase (AMPK) is a metabolic energy regulator found in a wide variety of cells and has been linked to cystic fibrosis transmembrane conductance regulator (CFTR) mediated chloride secretion in several different tissues. We hypothesized that AMPK mediates many of the acute effects of hypoxia on human and rat colonic electrolyte transport.


Useful keywords (using NLM MeSH Indexing)

AMP-Activated Protein Kinases/physiology*

Animals

Cell Hypoxia/physiology*

Chloride Channels/physiology*

Chlorides/metabolism*

Colon/blood supply*

Cystic Fibrosis Transmembrane Conductance Regulator/antagonists*

inhibitors*

Humans

Intestinal Mucosa/blood supply*

Ischemia/physiopathology*

Male

Membrane Potentials/physiology

Microscopy, Fluorescence

Rats

Rats, Sprague-Dawley