PMU-Autor/inn/en
Aigner LudwigAbstract
The pathological mechanism in acute spinal cord injury (SCI) is dual sequential: the primary mechanical lesion and the secondary injury due to a cascade of biochemical and pathological changes initiated by the primary lesion. Therapeutic approaches have focused on modulating the mechanisms of secondary injury. Despite extensive efforts in the treatment of SCI, there is yet no causal, curative treatment approach available. Extracorporeal shock wave therapy (ESWT) has been successfully implemented in clinical use. Biological responses to therapeutic shock waves include altered metabolic activity of various cell types due to direct and indirect mechanotransduction leading to improved migration, proliferation, chemotaxis, modulation of the inflammatory response, angiogenesis, and neovascularization, thus inducing rather a regeneration than repair. The aim of this clinical study is to investigate the effect of ESWT in humans within the first 48 h after an acute traumatic SCI, with the objective to intervene in the secondary injury phase in order to reduce the extent of neuronal loss.
Useful keywords (using NLM MeSH Indexing)
Double-Blind Method
Extracorporeal Shockwave Therapy*
Humans
Mechanotransduction, Cellular
Multicenter Studies as Topic
Prospective Studies
Quality of Life
Randomized Controlled Trials as Topic
Sensation
Spinal Cord Injuries*/diagnosis
Spinal Cord Injuries*/therapy
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Spinal cord injuries