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Forschungsdatenbank PMU-SQQUID

Favourable response to plasma exchange in tumefactive CNS demyelination with delayed B-cell response
Seifert, CL; Wegner, C; Sprenger, T; Weber, MS; Bruck, W; Hemmer, B; Sellner, J
MULT SCLER J. 2012; 18(7): 1045-1049.
Originalarbeiten (Zeitschrift)

PMU-Autor/inn/en

Sellner Johann

Abstract

We report a case of multiple sclerosis-associated fulminant tumefactive demyelinating lesion (TDL) with the special feature of delayed humoral immune response. Plasma exchange (PE) yielded significant benefit in two consecutive steroid-unresponsive relapses, while signs of an intrathecal B-cell response were only present 2 years later at the second relapse. Remission was achieved and sustained thereafter with natalizumab. Our case indicates that PE might be a therapeutic option even when the B-cell response is not fully developed. This delay in the development of a humoral immune response may reflect the step-wise B-cell colonization of the CNS and represent an attractive therapeutic window of opportunity.


Useful keywords (using NLM MeSH Indexing)

Adult

Antibodies, Monoclonal, Humanized/therapeutic use

B-Lymphocytes/immunology

Brain/pathology*

Demyelinating Diseases/etiology

Demyelinating Diseases/immunology

Demyelinating Diseases/therapy

Disease Progression

Flow Cytometry

Humans

Magnetic Resonance Imaging

Male

Multiple Sclerosis/complications*

Multiple Sclerosis/immunology*

Multiple Sclerosis/pathology*

Multiple Sclerosis/therapy

Plasma Exchange*

T-Lymphocytes/immunology


Find related publications in this database (Keywords)

humoral immune response
immunopathogenesis
multiple sclerosis
plasma exchange
treatment
tumefactive demyelination