Forschungsdatenbank PMU-SQQUID

PMU-Autor/inn/en

Abstract

Although sleep apnea (SA) is a risk factor for ischemic stroke and an important prognostic factor in affected patients, the exact pathophysiological link between SA and stroke is unknown. We investigated whether the plasma concentration of biomarkers of inflammation and endothelial dysfunction, including soluble tumor necrosis factor receptor-1 and -2 (sTNF-R1 and sTNF-R2), tumor necrosis factor-β (TNF-β), soluble intercellular cell adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) are increased in patients with acute stroke and SA compared with stroke patients without SA.

Useful keywords (using NLM MeSH Indexing)

Adult

Aged

Aged, 80 and over

Biological Markers

Endothelium, Vascular/pathology*

Female

Fibrinogen/metabolism

Humans

Inflammation/blood*

Intercellular Adhesion Molecule-1/blood

Lymphotoxin-alpha/blood

Male

Middle Aged

Neurologic Examination

Polysomnography

Receptors, Interleukin-4/blood

Receptors, Tumor Necrosis Factor, Type I/blood

Receptors, Tumor Necrosis Factor, Type II/blood

Risk Factors

Sleep Apnea Syndromes/blood*

Sleep Apnea Syndromes/complications

Sleep Apnea Syndromes/diagnosis

Stroke/blood*

Stroke/complications

Stroke/diagnosis

Vascular Cell Adhesion Molecule-1/blood

Vascular Diseases/blood*

Vascular Diseases/pathology

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