PMU-Autor/inn/en
Kral MichaelAbstract
Here, we report on a patient presenting with two histopathologically distinct gliomas. At the age of 42, the patient underwent initial resection of a right temporal oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade II followed by adjuvant radiochemotherapy with temozolomide. 15 months after initial diagnosis, the patient showed right hemispheric tumor progression and an additional new left frontal contrast enhancement in the subsequent imaging. A re-resection of the right-sided tumor and resection of the left frontal tumor were conducted. Neuropathological work-up showed recurrence of the right-sided oligodendroglioma with features of an anaplastic oligodendroglioma WHO Grade III, but a glioblastoma WHO grade IV for the left frontal lesion. In depth molecular profiling revealed two independent brain tumors with distinct molecular profiles of anaplastic oligodendroglioma IDH mutated 1p/19q co-deleted WHO Grade III and glioblastoma IDH wildtype WHO grade IV. This unique and rare case of a patient with two independent brain tumors revealed by in-depth molecular work-up and epigenomic profiling emphasizes the importance of integrated work-up of brain tumors including methylome profiling for advanced patient care.
Useful keywords (using NLM MeSH Indexing)
Astrocytoma*/pathology
Biology
Brain Neoplasms*/diagnosis
Brain Neoplasms*/genetics
Brain Neoplasms*/therapy
Chromosomes, Human, Pair 1
DNA
Glioblastoma*/genetics
Glioblastoma*/pathology
Glioblastoma*/therapy
Glioma*/pathology
Humans
Isocitrate Dehydrogenase/genetics
Methylation
Mutation
Oligodendroglioma*/diagnosis
Oligodendroglioma*/genetics
Oligodendroglioma*/therapy
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