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Forschungsdatenbank PMU-SQQUID

Heparin and Derivatives for Advanced Cell Therapies.
Laner-Plamberger, S; Oeller, M; Rohde, E; Schallmoser, K; Strunk, D;
Int J Mol Sci. 2021; 22(21):
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PMU-Autor/inn/en

Laner-Plamberger Sandra
Öller Michaela
Rohde Eva
Schallmoser Katharina
Strunk Dirk

Abstract

Heparin and its derivatives are saving thousands of human lives annually, by successfully preventing and treating thromboembolic events. Although the mode of action during anticoagulation is well studied, their influence on cell behavior is not fully understood as is the risk of bleeding and other side effects. New applications in regenerative medicine have evolved supporting production of cell-based therapeutics or as a substrate for creating functionalized matrices in biotechnology. The currently resurgent interest in heparins is related to the expected combined anti-inflammatory, anti-thrombotic and anti-viral action against COVID-19. Based on a concise summary of key biochemical and clinical data, this review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins.


Useful keywords (using NLM MeSH Indexing)

Anticoagulants/adverse effects

Anticoagulants/chemistry*

Anticoagulants/therapeutic use

Biocompatible Materials/chemistry

Biocompatible Materials/therapeutic use

Cell Adhesion

Cell- and Tissue-Based Therapy/methods*

Hemorrhage/etiology

Heparin/adverse effects

Heparin/analogs*

derivatives*

Heparin/therapeutic use

Humans

Mesenchymal Stem Cells/cytology

Mesenchymal Stem Cells/metabolism

Regenerative Medicine

Thromboembolism/drug therapy


Find related publications in this database (Keywords)

heparin
cell therapy
regenerative medicine
biomaterials
human platelet lysate
extracellular vesicles