PMU-Autor/inn/en
Laner-Plamberger SandraAbstract
Heparin and its derivatives are saving thousands of human lives annually, by successfully preventing and treating thromboembolic events. Although the mode of action during anticoagulation is well studied, their influence on cell behavior is not fully understood as is the risk of bleeding and other side effects. New applications in regenerative medicine have evolved supporting production of cell-based therapeutics or as a substrate for creating functionalized matrices in biotechnology. The currently resurgent interest in heparins is related to the expected combined anti-inflammatory, anti-thrombotic and anti-viral action against COVID-19. Based on a concise summary of key biochemical and clinical data, this review summarizes the impact for manufacturing and application of cell therapeutics and highlights the need for discriminating the different heparins.
Useful keywords (using NLM MeSH Indexing)
Anticoagulants/adverse effects
Anticoagulants/chemistry*
Anticoagulants/therapeutic use
Biocompatible Materials/chemistry
Biocompatible Materials/therapeutic use
Cell Adhesion
Cell- and Tissue-Based Therapy/methods*
Hemorrhage/etiology
Heparin/adverse effects
Heparin/analogs*
derivatives*
Heparin/therapeutic use
Humans
Mesenchymal Stem Cells/cytology
Mesenchymal Stem Cells/metabolism
Regenerative Medicine
Thromboembolism/drug therapy
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heparin