PMU-Autor/inn/en
Ebner PatriciaAbstract
Self-assembly of solid organs from single cells would greatly expand applicability of regenerative medicine. Stem/progenitor cells can self-organize into micro-sized organ units, termed organoids, partially modelling tissue function and regeneration. Here we demonstrated 3D self-assembly of adult and induced pluripotent stem cell (iPSC)-derived fibroblasts, keratinocytes and endothelial progenitors into both, planar human skin in vivo and a novel type of spheroid-shaped skin organoids in vitro, under the aegis of human platelet lysate.
Useful keywords (using NLM MeSH Indexing)
Adult
Animals
Cell Culture Techniques/methods*
Cell Differentiation/physiology
Endothelial Cells/cytology
Endothelial Progenitor Cells/cytology
Endothelial Progenitor Cells/physiology
Female
Fibroblasts/cytology
Fibroblasts/physiology
Healthy Volunteers
Humans
Induced Pluripotent Stem Cells/metabolism
Keratinocytes/cytology
Keratinocytes/physiology
Male
Mice, Inbred NOD
Middle Aged
Organoids/cytology
Organoids/metabolism*
Regeneration/physiology
Regenerative Medicine
Skin/metabolism
Skin Physiological Phenomena/genetics*
Stem Cells/metabolism*
Transfection
Find related publications in this database (Keywords)
Skin organoids